中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (42): 7878-7882.doi: 10.3969/j.issn.1673-8225.2010.42.021

• 生物材料综述 biomaterial review • 上一篇    下一篇

药物洗脱支架的药物装载方式及应用

陈文平1，詹红兵1，李昭辉2　   

  1. 1福州大学材料科学与工程学院，福建省福州市  350108；2 厦门大学附属中山医院血管外科，福建省厦门市 361004　
  • 出版日期:2010-10-15 发布日期:2010-10-15
  • 通讯作者: 詹红兵，博士，教授，博士生导师，福州大学材料科学与工程学院，福建省福州市 350108 hbzhan@fzu.edu.cn 李昭辉，博士，副主任医师，厦门大学附属中山医院血管外科，福建省厦门市361004 zhaohli@xmu.edu.cn
  • 作者简介:陈文平★，女，1985年生，福建省永泰县人，汉族，福州大学在读硕士，主要从事有机-无机复合心血管支架药物控释涂层材料方面的研究。 wpchen1985@163.com
  • 基金资助:

    福建省科技厅资助省属高校项目（2008F50303）。

Drug loading strategies and applications of drug eluting stents

Chen Wen-ping1, Zhan Hong-bing1, Li Zhao-hui2   

  1. 1 College of Materials Science and Engineering, Fuzhou University, Fuzhou   350108, Fujian Province, China; 2 Department of Vascular Surgery, Zhongshan Hospital of Xiamen University, Xiamen   361004, Fujian Province, China
  • Online:2010-10-15 Published:2010-10-15
  • Contact: Zhan Hong-bing, Doctor, Professor, Doctoral supervisor, College of Materials Science and Engineering, Fuzhou University, Fuzhou 350108, Fujian Province, China hbzhan@fzu.edu.cn Li Zhao-hui, Doctor, Associate chief physician, Department of Vascular Surgery, Zhongshan Hospital of Xiamen University, Xiamen 361004, Fujian Province, China zhaohli@xmu.edu.cn
  • About author:Chen Wen-ping★, Studying for master’s degree, College of Materials Science and Engineering, Fuzhou University, Fuzhou 350108, Fujian Province, China wpchen1985@163.com
  • Supported by:

     the Higher Institute Foundation of Fujian Province Science and Technology Bureau, No. 2008F50303*

PDF

422

被引次数

4

摘要：

背景：药物释放动力学不理想、高分子载体引起的后期血栓和涂层完整性破坏等是目前药物洗脱支架面临的主要问题。要从根本上解决这些问题，就需要改变支架上药物的装载方式，包括药物和载体的选择以及药物涂层的制备工艺。
目的：讨论目前药物洗脱支架的药物装载方式，探索其可能的发展方向。
方法：应用计算机检索 Elsevier、ACS和Springerlink数据库中 2000-03/2010-01关于药物洗脱支架涂层的文章，在标题中以 “stent; drug; coating ”为检索词进行检索。选择文章内容与药物洗脱支架涂层有关者，同一领域文献则选择发表在权威杂志的文章。初检得到445篇文献，根据纳入标准选择关于药物洗脱支架涂层制备的31篇文章进行综述。
结果与结论：目前研究的药物洗脱支架涂层按照药物与其载体间的结合方式可分为物理装载，静电吸附和化学键合。文章分别讨论了不同体系的药物、载体、涂层制备、释放动力学和降低再狭窄效果，指出不同的药物根据其自身的生物、物理和化学性质，可以选择合适的载体和改变涂层制备工艺，从而达到相对理想的释放动力学。另外还展望了药物洗脱支架涂层的未来发展方向，有望为该领域提供新的思路和方法。

关键词: 药物洗脱支架, 涂层制备, 药物装载, 药物载体, 释放动力学, 支架再狭窄　

Abstract:

BACKGROUND: Undesirable drug release profile, late stent thrombosis associated with polymer and failure to maintain coating integrity are the main current problems in the field of drug eluting stents (DESs). The most original way to address these problems is to change the drug loading strategies including the choice of drug and drug carrier, as well as coating preparation technology.
OBJECTIVE: To review the current loading strategies for DESs and to explore the potential future directions.
METHODS: Databases of Elsevier, ACS and Springerlink were retrieved using key words of “stent, drug, coating” to search papers about the DESs coating published from March 2000 to January 2010. Related papers addressing DESs coatings were selected. Articles published in authority journals were preferred in the same field. Totally 445 literatures were initially searched, according to inclusive criteria, 31 literatures were summarized.
RESULTS AND CONCLUSION: According to the bonding mode between drugs and carriers, the DESs can be divided into physically incorporated, electrostatically attracted and covalently bonded carriers. Various systems of drugs, carriers, coating preparations were discussed from the perspective of drug release profile and anti-restenosis efficiency, which indicated that a relatively desirable release profile can be achieved by careful choice of drug carrier and coating technology based on the physiochemical properties of the drug to be loaded. The potential future directions provided in this paper represented a new clue for optimizing DESs.

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