中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (40): 7555-7559.doi: 10.3969/j.issn.1673-8225.2010.40.033

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞体外培养及其归巢机制

覃基政，韩晓冬   

  1. 南京大学医学院，江苏省南京市  210093
  • 出版日期:2010-10-01 发布日期:2010-10-01
  • 通讯作者: 韩晓冬，教授，博士生导师，南京大学医学院，江苏省南京市 210093 hanxd@nju.edu.cn
  • 作者简介:覃基政★，男，1987年生，广西壮族自治区河池市人，仫佬族，南京大学医学院在读硕士，主要从事骨髓间充质干细胞的研究。 qinjizheng@126.com

In vitro culture and homing mechanism of bone marrow mesenchymal stem cells

Qin Ji-zheng, Han Xiao-dong   

  1. Medical College, Nanjing University, Nanjing  210093, Jiangsu Province, China
  • Online:2010-10-01 Published:2010-10-01
  • Contact: Han Xiao-dong, Professor, Doctoral supervisor, Medical College, Nanjing University, Nanjing 210093, Jiangsu Province, China hanxd@nju.edu.cn
  • About author:Qin Ji-zheng★, Studying for Master’s degree, Medical College, Nanjing University, Nanjing 210093, Jiangsu Province, China qinjizheng@126.com

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摘要：

背景：骨髓间充质干细胞具有多向分化潜能的特性，体外可多次传代培养，在特定的情况下，多种因子参与调控其到达损伤的组织器官进行修复重建。
目的：综述骨髓间充质干细胞归巢机制及其临床应用前景。
方法：应用计算机检索1999-01/2008-12 SCI数据库相关文章，检索词为“bone marrow mesenchymal stem cell，homing，clinical，therapy”，并限定文章语言种类为English。共检索到文献66篇。
结果与结论：骨髓间充质干细胞是存在于骨髓中除造血干细胞以外的另一类具有“无限”增殖和多向分化潜能的干细胞。在一定的诱导条件下，这类细胞可归巢到特定的组织并分化为相应组织细胞，发挥修复重建作用，此外，它还具有易提取、扩增能力强、不存在伦理问题和排斥反应等优点，由于这些优点，其将成为当今社会医学领域中很多难治之症的希望所在。

关键词: 归巢, 骨髓间充质干细胞, 体外培养, 进展, 综述文献

Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) have multi-directional differentiation potential, and can subculture in vitro. Under special conditions, multiple factors participate in regulating BMSCs towards damaged tissue organs for repair and reestablishment.
OBJECTIVE: To review BMSCs homing mechanism and clinical application in the future.
METHODS: A computer-based online search was performed in SCI database for articles published from January 1999 to December 2008. The key words were “bone marrow mesenchymal stem cell, homing, clinical, therapy” in English. Totally 66 articles were retrieved.
RESULTS AND CONCLUSION: BMSCs are a kind of stem cells with potential of infinite proliferation and multi-directional differentiation, besides hematopoietic stem cells. Under special induced conditions, BMSCs can homing to a specific tissue and differentiate into corresponding tissue cells, resulting in playing repair and reestablishment effects. In addition, BMSCs are easy to be extracted, with strong amplification ability, no ethical problem or rejection. Therefore, BMSCs have a bright future in the clinical application to many obstinate diseases.

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