中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (3): 513-516.doi: 10.3969/j.issn.1673-8225.2010.03.032

• 生物材料综述 biomaterial review • 上一篇    下一篇

MR对比剂超顺磁性氧化铁脂质体的研究现状：标记特点及其安全性和局限性

戴  懿1，吴元魁2   

  1. 1南方医科大学第一临床医学院，广东省广州市 510515；2南方医科大学南方医院影像中心，广东省深圳市  510515
  • 出版日期:2010-01-15 发布日期:2010-01-15
  • 通讯作者: 吴元魁，博士，主治医师，南方医科大学南方医院影像中心，广东省广州市 510515 ripleyor@126.com
  • 作者简介:戴 懿，男，1987年生，广东省广州市人，南方医科大学第一临床医学院2006级影像本科学生。

Research status of superparamagnetic iron oxide MR contrast agent: Marking features, safety and limitation

Dai Yi1, Wu Yuan-kui2   

  1. 1 First Clinical Medical College, Southern Medical University, Shenzhen   510515, Guangdong Province, China; 2 Imaging Center, Nanfang Hospital, Southern Medical University, Shenzhen   510515, Guangdong Province, China
  • Online:2010-01-15 Published:2010-01-15
  • Contact: Wu Yuan-kui, Doctor, Attending physician, Imaging Center, Nanfang Hospital, Southern Medical University, Shenzhen 510515, Guangdong Province, China ripleyor@126.com
  • About author:Dai Yi, First Clinical Medical College, Southern Medical University, Shenzhen 510515, Guangdong Province, China

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摘要：

背景：近年来超顺磁性氧化铁(superparamagnetic iron oxide, SPIO)对比剂的研发受到了广泛关注，主要体现在干细胞移植后追踪成像、包裹有阿拉伯半乳聚糖的细胞膜受体靶向成像以及SPIO脂质体等剂型的研究方面。
目的：对MR对比剂SPIO脂质体的研究现状做一综述。
方法：应用计算机检索CNKI和Science Direct数据库中1998-01/2009-09关于超顺磁性氧化铁脂质体的文章，在标题和摘要中以“SPIO，超顺磁性氧化铁，脂质体，MR对比剂”或“SPIO, superparamagnetic iron oxide, Liposome, MR contrast agent”为检索词进行检索。选择文章内容与MR对比剂有关者，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到48篇文献，根据纳入标准选择关于超顺磁性氧化铁脂质体的24篇文献及1部著作进行综述。

结果与结论：MR对比剂的不断创新改良对MRI诊断技术的提高起到了不可磨灭的作用。超顺磁性对比剂的代表SPIO在多种疾病的诊断价值上超越了以往的MR对比剂。SPIO脂质体具有更低的毒副作用以及对特异组织良好的靶向性，在实验研究及临床应用上受到广泛关注并被逐步推广。随着功能影像和分子影像的迅速发展，SPIO脂质体在今后应用领域必将更为宽广。

关键词: 超顺磁性氧化铁, 脂质体, 超顺磁性氧化铁脂质体, 对比剂, 磁共振成像

Abstract:

BACKGROUND: Superparamagnetic iron oxide (SPIO) contrast agent has been extensively explore in tracing imaging following stem cell transplantation, arabinogalactan cell membrane receptor targeted imaging, as well as liposome-coated SPIO.
OBJECTIVE: To summarize the research state of liposome-coated SPIO.
METHODS: A computer-based online search of CNKI and Science Direct (1998-01/2009-09) was performed to search the articles about liposome-coated SPIO with key words “SPIO, superparamagnetic iron oxide, liposome, MR contrast agent” in Chinese and English. Articles related to MR contrast agent, and published in recently or authorial journals of the same field were included. A total of 48 articles were collected, and 24 articles and 1 composition related to liposome-coated SPIO were reviewed.
RESULTS AND CONCLUSION: The incessant innovation in MR contrast agents can greatly improve the diagnosis of MRI. Due to the good performances, diagnostic value of SPIO in many diseases has surpassed previous MR contrast agents. Liposome-coated SPIO has the merits of low toxic side effect, and well targeting in specific tissues, thereby extensively being used in experimental studies and clinical application. With the development of functional imaging and molecular imaging, the use of liposome-coated SPIO must be more extensive.

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