中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (19): 5082-5092.doi: 10.12307/2026.789

• 干细胞相关大数据分析 Stem cell-related big data analysis • 上一篇    

外泌体与神经病理性疼痛：文献可视化分析

马  婧1，韩  静2，施琳玉1，吴宇蔚3，袁海光1，4，李永丰1，3   

  1. 1陕西中医药大学针灸推拿学院，陕西省咸阳市  712046；2陕西师范大学教育学院，陕西省西安市  710062；3中医药前沿交叉科学技术研究院，陕西省咸阳市  712046；4陕西中医药大学附属医院，陕西省咸阳市  712000
  • 收稿日期:2025-09-11 接受日期:2025-11-21 出版日期:2026-07-08 发布日期:2026-02-24
  • 通讯作者: 李永丰，博士，副教授，硕士研究生导师，陕西中医药大学针灸推拿学院，陕西省咸阳市 712046；中医药前沿交叉科学技术研究院，陕西省咸阳市 712046
  • 作者简介:马婧，女，1992年生，陕西省汉中市人，汉族，陕西中医药大学在读硕士，主要从事针灸作用的神经科学机制方面研究。
  • 基金资助:
    陕西省青年科技新星项目(2025ZC-KJXX-70)，项目负责人：李永丰；国家自然科学基金项目(82004489)，项目负责人：李永丰；秦创原中医药产业创新聚集区项目(中医药大学﹑医疗机构)(L2024-QCY-ZYYJJQ-X154)，项目负责人：李永丰；咸阳市重点研发计划项目(L2014-ZDYF-ZDYF-SF-0036)，项目负责人：李永丰；国家自然科学基金项目(82205263)，项目负责人：吴宇蔚；陕西省自然科学基础研究计划项目(2024JC-YBMS-796)，项目负责人：袁海光

Exosomes and neuropathic pain: visualization analysis on literature

Ma Jing1, Han Jing2, Shi Linyu1, Wu Yuwei3, Yuan Haiguang1, 4, Li Yongfeng1, 3   

  1. 1College of Acupuncture-Moxibustion and Tuina, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China; 2College of Education, Shaanxi Normal University, Xi’an 710062, Shaanxi Province, China; 3Institute of Frontier Cross-Science and Technology of Chinese Medicine, Xianyang 712046, Shaanxi Province, China; 4Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China
  • Received:2025-09-11 Accepted:2025-11-21 Online:2026-07-08 Published:2026-02-24
  • Contact: Li Yongfeng, PhD, Associate professor, Master’s supervisor, College of Acupuncture-Moxibustion and Tuina, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China; Institute of Frontier Cross-Science and Technology of Chinese Medicine, Xianyang 712046, Shaanxi Province, China
  • About author:Ma Jing, MS candidate, College of Acupuncture-Moxibustion and Tuina, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China
  • Supported by:
    Shaanxi Province Young Science and Technology Rising Star Project, No. 2025ZC-KJXX-70 (to LYF); National Natural Science Foundation of China, No. 82004489 (to LYF); Qinchuangyuan Traditional Chinese Medicine Industry Innovation Aggregation Zone Project (University of Traditional Chinese Medicine, Medical Institutions), No. L2024-QCY-ZYYJJQ-X154 (to LYF); Xianyang Key Research and Development Program Project, No. L2014-ZDYF-ZDYF-SF-0036 (to LYF); National Natural Science Foundation of China, No. 82205263 (to WYW); Shaanxi Province Natural Science Basic Research Program Project, No. 2024JC-YBMS-796 (to YHG)

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摘要：

文题释义：

外泌体：是广泛存在于体液(如血液、尿液等)和细胞培养上清中的小型膜囊泡，直径通常在30-150 nm之间。它们通过携带多种生物活性分子，如蛋白质、脂质和核酸，在细胞间通讯和免疫调节过程中发挥重要的生物学功能。
可视化分析：是一种利用图形、图像、交互界面等可视化手段，对数据进行探索、分析和展示的方法。

摘要
背景：神经病理性疼痛发病机制复杂且临床干预效果有限。近年来，外泌体因独特的细胞间通讯功能和分子递送能力，逐渐成为神经病理性疼痛研究的热点。
目的：通过文献计量学方法，系统梳理外泌体在神经病理性疼痛领域的研究进展，总结知识结构与研究热点，为该领域发展提供理论依据与转化策略。
方法：基于Web of Science核心合集(WOSCC)数据库，检索外泌体与神经病理性疼痛的相关文献，检索时间跨度为2012-01-01/2025-03-31，利用VOSviewer和CiteSpace软件进行关键词共现、聚类分析、突现词检测及合作网络可视化。
结果与结论：共筛选出313篇文献纳入研究范畴。在42个国家或地区中，美国和中国作出了重大贡献。上海交通大学和南通大学是发表论文最多的研究机构。研究最多、被共同引用最多的期刊分别是《Neural Regeneration Research》和《International Journal of Molecular Sciences》。研究共识别出382位作者，张正刚的文章数量最多，张毅的论文被引用次数最多。重点关注的关键词包括“nerve regeneration”“neuroinflammation”“schwann cell”“regenerative medicine”和“spinal cord injury”，这些都是未来发展的重点研究领域。通过文献计量学分析，梳理了外泌体在神经病理性疼痛领域的研究趋势。外泌体在神经病理性疼痛的基础机制解析和新型精准治疗具备广阔前景，未来可结合多组学、工程化外泌体平台等技术手段来推动该领域的发展。

关键词: 神经病理性疼痛, 外泌体, CiteSpace, 文献计量学, 可视化分析, 疼痛管理, 生物标志物, 治疗潜力

Abstract: BACKGROUND: Neuropathic pain has a complex pathogenesis and limited clinical intervention outcomes. In recent years, exosomes have gradually emerged as a focal point in the study of neuropathic pain due to their unique intercellular communication functions and molecular delivery capabilities.
OBJECTIVE: To systematically review research progress on exosomes in the field of neuropathic pain using bibliometric methods, summarize the knowledge framework and research hotspots, and provide theoretical foundations and translational strategies for advancing this field.
METHODS: Based on the Web of Science Core Collection (WOSCC) database, relevant literature on exosomes and neuropathic pain was retrieved over the time span from January 1, 2012, to March 31, 2025. Keyword co-occurrence analysis, clustering analysis, outbreak detection, and collaboration network visualization were performed using VOSviewer and CiteSpace software.
RESULTS AND CONCLUSION: A total of 313 articles were included in this study. Among 42 countries or regions, the United States and China made significant contributions. Shanghai Jiao Tong University and Nantong University were the research institutions with the highest number of publications. The journals with the most publications and the highest number of citations were Neural Regeneration Research and International Journal of Molecular Sciences, respectively. The study identified 382 authors, with Zhang Zheng Gang having the highest number of publications and Zhang Yi having the highest number of citations. Keywords of particular interest included “nerve regeneration,” “neuroinflammation,” “Schwann cell,” “regenerative medicine,” and “spinal cord injury,” all of which are key areas for future research. Bibliometric analysis revealed research trends of exosomes in the field of neuropathic pain. Exosomes hold great promise in elucidating the underlying mechanisms and developing novel precision therapies for neuropathic pain. Future studies may combine multi-omics and engineered exosome platforms to advance the development of this field.


Key words: neuropathic pain, exosome, CiteSpace, bibliometrics, visualization analysis, pain management, biomarkers, therapeutic potential

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