中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (19): 5072-5081.doi: 10.12307/2026.282

• 干细胞相关大数据分析 Stem cell-related big data analysis • 上一篇    下一篇

外泌体促进糖尿病创面愈合：研究热点及演化趋势的可视化分析

简喜超，邵靖杰，唐诗涵，祁  放，邓呈亮   

  1. 遵义医科大学附属医院烧伤整形外科，贵州省遵义市   563003
  • 收稿日期:2025-09-23 接受日期:2025-12-08 出版日期:2026-07-08 发布日期:2026-02-24
  • 通讯作者: 邓呈亮，博士，主任医师，遵义医科大学附属医院烧伤整形外科，贵州省遵义市 563003
  • 作者简介:简喜超，男，1996年生，在读硕士，主要从事糖尿病创面修复研究。
  • 基金资助:
    国家自然科学基金项目(82160379)，项目负责人：祁放

Exosomes promote diabetic wound healing: a visual analysis of research hotspots and evolutionary trends

Jian Xichao, Shao Jingjie, Tang Shihan, Qi Fang, Deng Chengliang   

  1. Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • Received:2025-09-23 Accepted:2025-12-08 Online:2026-07-08 Published:2026-02-24
  • Contact: Deng Chengliang, MD, Chief physician, Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • About author:Jian Xichao, MS candidate, Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • Supported by:
    National Natural Science Foundation of China, No. 82160379 (to QF)

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摘要：

文题释义：

外泌体：是直径30-150 nm的细胞源纳米囊泡，通过携带功能性蛋白、核酸及脂质等生物分子介导细胞间通讯。
可视化分析：是一种将数据转化为图形、图表及空间映射等直观视觉表征的核心技术，通过揭示数据间的内在关联、动态趋势和潜在规律，赋能研究者快速识别关键信息、验证科学假设并支撑循证决策的方法。

摘要
背景：糖尿病创面是糖尿病患者严重并发症之一，其复杂的病理机制和临床治疗困境仍是重大挑战。近年来，外泌体因在细胞间通讯、免疫调节及组织修复中发挥关键作用，已成为糖尿病创面研究领域的新焦点。
目的：探讨外泌体在糖尿病创面研究领域的热点和演化趋势。
方法：检索Web of Science核心合集数据库中外泌体在糖尿病创面领域相关研究的英文文献，检索时限为建库至2024-12-31，统计年度发文量分析变化趋势。采用VOSviewer和CiteSpace软件对纳入的文献进行可视化分析，包括作者、国家、机构、期刊和关键词，探讨外泌体在糖尿病创面愈合中的研究现状和热点的演变过程。

结果与结论：2014-2024年，外泌体促进糖尿病创面愈合相关文献共424篇，这些文献来自46个国家的2 883名作者，发表在199个期刊上。在外泌体促进糖尿病创面愈合的相关研究中，中国发文数量最多，其次是美国；《Journal of Nanobiotechnology》和《Advanced Healthcare Materials》杂志发表的论文数量最多，具有较高的影响力；作者Chen zhenbing和华中科技大学分别是最具生成力的作者和机构，但研究者集群尚未达到一定规模，未来仍需加强团队合作。全球研究焦点主要集中在脂肪干细胞、糖尿病创面、糖尿病创面愈合、创面愈合、内质网应激、微泡、胶原蛋白、蛋白组学和糖尿病足感染等10个主题群，该领域的研究热点正经历分子机制到系统干预的转变，未来的研究热点集中在血管生成、巨噬细胞、抗菌和水凝胶等方面，在此基础上融合多学科技术实现更加有效的精准治疗，优化糖尿病创面的管理策略。

https://orcid.org/0009-0002-0394-4050 (简喜超)；https://orcid.org/0000-0002-6593-3245 (邓呈亮) 


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 外泌体, 糖尿病, 糖尿病创面, 创面愈合, 可视化分析

Abstract: BACKGROUND: Diabetes wound is one of the serious complications of diabetes patients, and its complex pathological mechanism and clinical treatment dilemma is still a major challenge. In recent years, exosomes have become a new focus in the field of diabetes wound research because they play a key role in intercellular communication, immune regulation, and tissue repair.
OBJECTIVE: To investigate the research hotspots and evolutionary trends of exosomes in diabetic wound healing.  
METHODS: A systematic search was conducted in the Web of Science core collection to identify English literature focusing on exosomes in diabetic wound healing and published between the inception of the database and December 31, 2024. The annual publication volume was analyzed to track changes over time. Visual analyses using VOSviewer and CiteSpace software were performed on the retrieved literature to examine key aspects such as authors, countries, institutions, journals, and keywords, providing insights into the current research landscape and evolving hot topics in exosomes for diabetic wound healing.  
RESULTS AND CONCLUSION: From 2014 to 2024, a total of 424 publications on exosome-promoted diabetic wound healing were produced, contributed by 2 883 authors from 46 countries and featured in 199 journals. In the realm of exosome-promoted diabetic wound healing research, China has emerged as the leading contributor, followed closely by the United States. The journals Journal of Nanobiotechnology and Advanced Healthcare Materials have published the highest number of papers and are recognized for their significant influence in the field. Notably, author Chen Zhenbing and Huazhong University of Science and Technology stand out as the most prolific author and institution, respectively. However, the researcher clusters have yet to attain a substantial scale, indicating that future efforts are necessary to enhance team collaboration. Global research focus is primarily concentrated on ten thematic groups, including adipose-derived stem cells, diabetic wounds, diabetic wound healing, wound healing, endoplasmic reticulum stress, microbubbles, collagen, proteomics, and diabetic foot infections. The research hotspots in this field are undergoing a transition from molecular mechanisms to systemic interventions. Future research trends will center on angiogenesis, macrophages, antimicrobial agents and hydrogels. It is essential to integrate multidisciplinary technologies on this basis to achieve more effective precision treatments and optimize management strategies for diabetic wounds.


Key words: exosomes, diabetes, diabetic wounds, wound healing, visual analysis

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