中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (11): 2877-2885.doi: 10.12307/2026.094

• 组织构建相关数据分析 Date analysis of organization construction • 上一篇    下一篇

日常饮食结构与膝关节结构性损伤：来自英国和芬兰数据库遗传关系的大数据分析

颜文戬1，李颖慧2，张  勇3   

  1. 1北京体育大学中国篮球运动学院，北京市   100084；2首都医科大学生物医学工程学院，北京市   100069；3中国篮球协会，北京市   100062

  • 收稿日期:2025-04-22 接受日期:2025-06-11 出版日期:2026-04-18 发布日期:2025-09-06
  • 通讯作者: 张勇，博士，研究员，中国篮球协会，北京市 100062
  • 作者简介:颜文戬，男，2001年生，山东省曲阜市人，汉族，北京体育大学在读硕士，主要从事体育教学、运动损伤研究。

Daily diet and structural damage of the knee joint: a large-scale genetic analysis based on UK and FinnGen databases

Yan Wenjian1, Li Yinghui2, Zhang Yong3   

  1. 1China Basketball College, Beijing Sport University, Beijing 100084, China; 2College of Biomedical Engineering, Capital Medical University, Beijing 100069, China; 3Chinese Basketball Association, Beijing 100062, China
  • Received:2025-04-22 Accepted:2025-06-11 Online:2026-04-18 Published:2025-09-06
  • Contact: Zhang Yong, PhD, Researcher, Chinese Basketball Association, Beijing 100062, China
  • About author:Yan Wenjian, MS candidate, China Basketball College, Beijing Sport University, Beijing 100084, China

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摘要：


文题释义：
孟德尔随机化：是一种以遗传变异为工具变量，遵循孟德尔定律，即相应的等位基因在胚胎形成时期随机分配且固定的原则，排除混杂因素对结果的影响，加强了因果推断证据的研究方法。
半月板损伤：指膝关节内半月板出现撕裂或其他形式的损伤，通常是由于过度扭转、直接撞击或长期磨损引起的。
膝关节内部紊乱：指膝关节病变的综合症候群，涉及滑膜、软骨和半月板病变、关节内游离体、关节囊或韧带损伤等，表现为肿胀、疼痛、弹响、交锁、打软腿、跛行等。

背景：膝关节结构性损伤是常见的运动系统疾病，包括半月板损伤和膝关节内部紊乱，严重影响运动员和老年人的生活质量。现有研究表明日常饮食结构可能影响膝关节结构性损伤的发生与发展，但其因果关系尚不明确。
目的：基于遗传学方法，探讨日常饮食结构与膝关节结构性损伤之间的因果关系，识别潜在的风险性与保护性饮食因素。
方法：采用双样本孟德尔随机化分析日常饮食结构与膝关节结构性损伤之间的因果关系，其中半月板损伤和膝关节内部紊乱数据集来源于FinnGen数据库，暴露因素数据集来自OpenGWAS和GWAS Catalog数据库，涉及20项常见饮食因素。以逆方差加权法为主要分析方法，联合MR-Egger回归法、加权中位数法、简单模式法与加权模式法进行补充验证，并通过敏感性分析检验结果的稳健性。
结果与结论：逆方差加权法结果显示，共有13种饮食因素与半月板损伤存在潜在因果关系；12种饮食因素与膝关节内部紊乱相关。其中，蔬菜消耗量(OR=2.59，P < 0.001)与半月板损伤风险升高显著相关；精神活性饮料消耗量(OR=1.26，P < 0.001)与膝关节内部紊乱风险增加显著相关；水果消耗量(OR=0.68，P < 0.001)与膝关节内部紊乱风险降低显著相关。上述结果基于欧洲人群的大样本遗传数据，揭示了饮食结构与膝关节结构性损伤之间的潜在因果关系，可为中国人群在相关疾病的营养干预与预防策略制定提供参考依据。
https://orcid.org/0009-0007-3149-8445 (颜文戬) 

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 孟德尔随机化, 日常饮食结构, 半月板损伤, 膝关节内部紊乱, 因果关系, 敏感性分析, 保护因素, 危险因素

Abstract: BACKGROUND:  Structural damage of the knee joint is a common musculoskeletal disorder, including meniscus injury and internal derangement of the knee, which severely impact the quality of life in athletes and elderly populations. Existing studies have shown that daily diet may influence the occurrence and progression of structural knee joint damage, but the causal relationship remains unclear. 
OBJECTIVE: To explore the causal relationship between daily diet and structural damage of the knee joint based on a genetic approach and to identify potential risk and protective factors. 
METHODS: Two-sample Mendelian randomization was conducted to explore the causal relationship between daily diet and structural damage of the knee joint. Outcome datasets for meniscus injury and internal derangement of the knee were obtained from the FinnGen database, while exposure datasets involving 20 dietary factors were derived from the OpenGWAS and GWAS Catalog databases. The inverse variance weighted method served as the primary analytical approach, supplemented by MR-Egger regression, weighted median, simple mode, and weighted mode method for validation. Sensitivity analyses were conducted to test the robustness of the results. 
RESULTS AND CONCLUSION: The inverse variance weighted method showed that 13 dietary factors were potentially causally associated with meniscus injury, while 12 dietary factors showed potential causal relationships with internal derangement of the knee. Notably, vegetable was a significant risk factor for meniscal injury (odds ratio [OR] = 2.59, P < 0.001). Similarly, psychoactive drink was a significant risk factor for internal derangement of the knee (OR = 1.26, P < 0.001). In contrast, fruit was a significant protective factor for internal derangement of the knee (OR = 0.68, P < 0.001). Based on the large-scale European population data, these findings provide a potential causal relationship between dietary structure and knee joint damage, which may offer a useful reference for disease prevention and nutritional intervention strategies in China.


Key words: Mendelian randomization, daily dietary structure, meniscus injury, internal derangement of the knee, causal relationship, sensitivity analysis, protective factor, risk factor 

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