中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (28): 6003-6011.doi: 10.12307/2025.460

• 组织工程口腔材料 tissue-engineered oral materials • 上一篇    下一篇

个性化Gyroid结构髁突假体设计及对关节盘的有限元分析

姜婷婷1，2，刘丹瑜1，2，姜至秀1，2，季俣辰1，2，曹怡琳1，2，宿玉成2，3，4，王心彧1，2   

  1. 1佳木斯大学，黑龙江省佳木斯市   154003；2黑龙江省口腔生物材料与临床应用重点实验室，佳木斯大学口腔医学工程研究中心，佳木斯大学附属口腔医院，黑龙江省佳木斯市   154007；3中国医学科学院北京协和医院口腔种植中心，北京市   100032；4北京瑞城口腔医院，北京口腔种植培训中心，北京市   100032
  • 收稿日期:2024-04-27 接受日期:2024-06-26 出版日期:2025-10-08 发布日期:2024-12-07
  • 通讯作者: 王心彧，副主任医师，硕士生导师，佳木斯大学，黑龙江省佳木斯市 154003；黑龙江省口腔生物材料与临床应用重点实验室，佳木斯大学口腔医学工程研究中心，佳木斯大学附属口腔医院，黑龙江省佳木斯市 154007
  • 作者简介:姜婷婷，女，1996 年生，黑龙江省哈尔滨市人，汉族，佳木斯大学口腔医学院在读硕士，执业医师，主要从事口腔颌面外科方向的研究。
  • 基金资助:
    黑龙江省自然科学基金项目(LH2022H089)，项目负责人：王心彧；黑龙江省卫生健康委科研课题项目(2020-314)，项目负责人：王心彧

Design of customized Gyroid condylar prosthesis and finite element analysis of articular disc

Jiang Tingting1, 2, Liu Danyu1, 2, Jiang Zhixiu1, 2, Ji Yuchen1, 2, Cao Yilin1, 2, Su Yucheng2, 3, 4, Wang Xinyu1, 2   

  1. 1Jiamusi University, Jiamusi 154003, Heilongjiang Province, China; 2Key Laboratory of Oral Biomaterials and Clinical Applications of Heilongjiang Province, Stomatology Engineering Experimental Center of Jiamusi University, Stomatology College of Jiamusi University, Jiamusi 154007, Heilongjiang Province, China; 3Dental Implant Center, Peking Union Medica College Hospital, Chinese Academy of Medical Sciences, Beijing 100032, China; 4Beijing Implant Training College (BITC), Beijing Citident Stomatology Hospital, Beijing 100032, China
  • Received:2024-04-27 Accepted:2024-06-26 Online:2025-10-08 Published:2024-12-07
  • Contact: Wang Xinyu, Associate chief physician, Master’s supervisor, Jiamusi University, Jiamusi 154003, Heilongjiang Province, China; Key Laboratory of Oral Biomaterials and Clinical Applications of Heilongjiang Province, Stomatology Engineering Experimental Center of Jiamusi University, Stomatology College of Jiamusi University, Jiamusi 154007, Heilongjiang Province, China
  • About author:Jiang Tingting, Master candidate, Practicing physician, Jiamusi University, Jiamusi 154003, Heilongjiang Province, China; Key Laboratory of Oral Biomaterials and Clinical Applications of Heilongjiang Province, Stomatology Engineering Experimental Center of Jiamusi University, Stomatology College of Jiamusi University, Jiamusi 154007, Heilongjiang Province, China
  • Supported by:
    Heilongjiang Natural Science Foundation Project, No. LH2022H089 (to WXY); Heilongjiang Provincial Health Commission Research Project, No. 2020-314 (to WXY)

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摘要：


文题释义：

Gyroid结构：三周期极小曲面平均曲率为零，具有全连通性、连接面平滑、高比表面积和可控性等特点，其中的典型曲面Gyroid 结构由2个相互交织的无限平面构成，具有复杂的连续曲面和孔隙结构。通过参数调整和变形控制可以对Gyroid结构进行自定义调整，以适应不同的应用需求。
3D打印个性化髁突假体：利用金属3D打印技术和计算机辅助设计技术设计与患者髁突高度匹配且固定板与患者颌骨形态贴合的个性化髁突假体，通过计算机辅助制造将个性化髁突假体用于治疗颞下颌关节疾病。相对于全关节置换手术，个性化髁突假体置换可以减小手术风险、减轻手术创伤、减少患者费用。


背景：人工髁突假体置换作为治疗颞下颌关节疾病的手术方式之一，不仅要恢复形态和功能，还要保证长期稳定的应用。

目的：设计个性化Gyroid结构髁突假体并进行有限元分析。 
方法：通过软件设计不同壁厚(250，350，450，550，650，750 µm)的Gyroid结构试件，分别进行有限元模拟压缩实验，检测试件的弹性模量，筛选出与下颌骨松质骨弹性模量相匹配且孔径满足成骨条件的Gyroid结构壁厚区间，对此区间进行细分并利用3D打印技术制作Gyroid结构试件，进行万能试验机力学压缩实验，通过弹性模量与抗压强度筛选符合下颌骨力学性能、孔径更易成骨且强度较小的Gyroid结构壁厚，进行后续实验。设计下颌骨个性化Gyroid结构髁突假体三维模型，分别模拟模型在自然咬合状态下对刃颌位、牙尖交错位的有限元分析。

结果与结论：①有限元分析结果显示，随着壁厚的增加，Gyroid结构试件的弹性模量升高，其中壁厚350，450，550，650，750 µm Gyroid结构试件的弹性模量与下颌骨松质骨弹性模量相匹配，由于后续实验需细分组别且550，650，750 µm壁厚组孔径(800-1 000 μm)在成骨范围内，故筛选出壁厚550，600，650，700，750 µm Gyroid结构试件进行万能试验机力学压缩实验；②力学压缩实验结果显示，随着壁厚的增加，Gyroid结构试件的弹性模量与抗压强度升高，其中壁厚550，600，650 µm Gyroid结构试件的弹性模量在下颌骨松质骨弹性模量范围内，最终选取壁厚650 μm、孔径900 μm进行下颌骨个性化Gyroid结构髁突假体三维模型构建；③下颌骨个性化Gyroid结构髁突假体三维模型有限元分析结果显示，对刃颌位关节盘应力主要集中在前中带下表面，牙尖交错位关节盘应力主要集中在下表面外侧，左右侧关节盘在对刃颌位、牙尖交错位的最大位移和等效应力相近，最大位移分别为0.031，0.030，0.028，0.018 mm，最大等效应力分别为2.87，2.30，2.73，1.71 MPa；④结果表明，壁厚650 μm Gyroid结构符合下颌骨力学性能，降低了钛合金强度、减轻了个性化Gyroid结构髁突假体对关节盘的损伤。

https://orcid.org/0009-0002-0601-2224 (姜婷婷) 

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: Gyroid结构, 壁厚, 髁突假体, 有限元分析, 关节盘, 颞下颌关节

Abstract: BACKGROUND: Condylar prosthesis replacement, as one of the surgical methods for the treatment of temporomandibular joint diseases, not only needs to restore the morphology and function, but also needs to ensure long-term stable application.
OBJECTIVE: To design finite element analysis of a customized Gyroid condylar prosthesis. 
METHODS: Gyroid structure specimens with different wall thicknesses (250, 350, 450, 550, 650, and 750 µm) were designed by software. Finite element simulation compression experiments were carried out to test the elastic modulus of the specimens. The Gyroid structure wall thickness range that matches the elastic modulus of mandibular cancellous bone and whose pore size meets the osteogenesis conditions was screened out. This range was subdivided and Gyroid structure specimens were made using 3D printing technology. Mechanical compression experiments were carried out on a universal testing machine. The Gyroid structure wall thickness that meets the mechanical properties of mandibular bone, has an easier osteogenesis and a smaller strength was screened out by elastic modulus and compressive strength, and subsequent experiments were carried out. A three-dimensional model of a customized Gyroid condylar prosthesis was designed, and the finite element analysis of the blade jaw position and cusp interdigitation position of the model under natural occlusion was simulated.
RESULTS AND CONCLUSION: (1) Finite element analysis results showed that with the increase of wall thickness, the elastic modulus of Gyroid structure specimens increased. The elastic modulus of Gyroid structure specimens with wall thickness of 350, 450, 550, 650, and 750 µm matched the elastic modulus of mandibular cancellous bone. Since the subsequent experiments needed to be subdivided into groups and the pore size of the 550, 650, and 750 µm wall thickness group (pore size 800-1 000 μm) was within the osteogenesis range. Gyroid structure specimens with wall thickness of 550, 600, 650, 700, and 750 µm were selected for mechanical compression experiments on a universal testing machine. (2) The results of mechanical compression experiments showed that with the increase of wall thickness, the elastic modulus and compressive strength of Gyroid structure specimens increased. The elastic modulus of Gyroid structure specimens with wall thickness of 550, 600, and 650 µm was within the elastic modulus of the mandibular cancellous bone. Finally, the wall thickness of 650 μm and the pore size of 900 μm were selected to construct the three-dimensional model of the mandibular customized Gyroid condylar prosthesis. (3) The results of finite element analysis of three-dimensional model of the mandibular customized Gyroid condylar prosthesis showed that the stress of the articular disc in the edge-to-edge occlusion was mainly concentrated on the lower surface of the anterior middle band, and the stress of the articular disc in the interposition of tooth tips was mainly concentrated on the lateral surface of the lower surface. The maximum displacement and the maximum equivalent stress of the left and right articular discs in the edge-to-edge occlusion and the interposition of tooth tips were similar. The maximum displacement was 0.031, 0.030, 0.028, and 0.018 mm, and the maximum equivalent stress was 2.87, 2.30, 2.73, and 1.71 MPa, respectively. (4) The results showed that the Gyroid structure with a wall thickness of 650 μm was consistent with the mechanical properties of the mandible, which reduced the strength of the titanium alloy and reduced the damage of the articular disc caused by the customized Gyroid condylar prosthesis. 

Key words: Gyroid structure, wall thickness, condylar prosthesis, finite element analysis, articular disc, temporomandibular joint

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