中国组织工程研究 ›› 2023, Vol. 27 ›› Issue (30): 4896-4903.doi: 10.12307/2023.559
• 生物材料综述 biomaterial review • 上一篇 下一篇
张晓宇,陈 琪,杨 兴,郝跃峰
收稿日期:
2022-09-08
接受日期:
2022-10-28
出版日期:
2023-10-28
发布日期:
2023-04-03
通讯作者:
郝跃峰,男,1967年生,汉族,博士,教授,主任医师,博士生导师,南京医科大学附属苏州医院,骨科与运动医学中心,江苏省苏州市 215000
作者简介:
张晓宇,男,1998年生,江苏省人,汉族,南京医科大学在读硕士,主要从事骨关节炎方向的临床及基础研究。
基金资助:
Zhang Xiaoyu, Chen Qi, Yang Xing, Hao Yuefeng
Received:
2022-09-08
Accepted:
2022-10-28
Online:
2023-10-28
Published:
2023-04-03
Contact:
Hao Yuefeng, MD, Professor, Chief physician, Doctoral supervisor, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215000, Jiangsu Province, China
About author:
Zhang Xiaoyu, Master candidate, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215000, Jiangsu Province, China
Supported by:
摘要:
文题释义:
聚乳酸-羟基乙酸共聚物:由乳酸和羟基乙酸两种单体按不同比例随机聚合而成,这种人工合成的聚合物具有生物相容性、降解性、无毒、成囊和成膜等优点,被广泛应用于生物医用工程、制药及现代化工业领域。结果与结论:①聚乳酸-羟基乙酸共聚物微球的理化性质与其乳酸和羟基乙酸比、分子质量和端基团等因素有关。目前,乳酸和羟基乙酸比例为75∶25、相对分子质量为75 000-10 0000,端羧基的聚乳酸-羟基乙酸共聚物在制备微球时应用较多。②现在常用的制备方法主要包括乳化法、微流控技术、电喷雾、喷雾干燥和超临界流体法。具体的制备方法需结合微球的应用需求及生产条件来选择,随着技术的成熟与进步,未来会有更稳定、高效的生产方式。③聚乳酸-羟基乙酸共聚物微球的修饰改性包括负载生长因子和药物、功能化修饰以及以微球为基础构建复合支架。负载生长因子可促进细胞分化、血管生成,从而促进骨组织的修复与再生;负载药物可治疗多种骨骼类疾病;复合无机矿物可以提高聚乳酸-羟基乙酸共聚物的力学性能,而且提供骨组织生长所需的微量元素,更多的被用于骨缺损的治疗;通过增加微球调控细胞的分泌与活性的能力,参与疾病的免疫调控,为疾病治疗提供新思路;以聚乳酸-羟基乙酸共聚物微球为基础的复合支架,在支架原有的优点外,还能增加微创递送药物、缓释药物的能力,但是距离临床应用还需进一步研究证实。④聚乳酸-羟基乙酸共聚物微球在未来有望根据骨组织工程的不同需求,制定不同的修饰方法,从而生产出针对不同疾病具有特定功能的微球。
https://orcid.org/0000-0003-1710-9830(张晓宇);https://orcid.org/0000-0001-9835-9561(郝跃峰)
中国组织工程研究杂志出版内容重点:生物材料;骨生物材料;口腔生物材料;纳米材料;缓释材料;材料相容性;组织工程
中图分类号:
张晓宇, 陈 琪, 杨 兴, 郝跃峰. 聚乳酸-羟基乙酸共聚物微球在骨组织工程中的应用[J]. 中国组织工程研究, 2023, 27(30): 4896-4903.
Zhang Xiaoyu, Chen Qi, Yang Xing, Hao Yuefeng. Application of poly(lactic-co-glycolic acid) copolymer microspheres in bone tissue engineering[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(30): 4896-4903.
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1.1.7 检索策略 以PubMed数据库检索策略为例,见图1。
1.1.8 检索文献量 初步检索英文文献 864篇,其中Web of science数据库241篇,PubMed数据库623篇。
1.3 文献及质量评估及数据的提取 共检索到英文文献864篇,阅读文章题目及摘要排除相关程度低、过于陈旧或重复的文献,共纳入83篇符合筛查标准的文献进行综述。文献[1-8]介绍了PLGA微球的应用情况,文献[9-22]介绍PLGA性质对微球的影响,文献[23-43]介绍PLGA微球的制备方法及优缺点,文献[44-83]介绍了PLGA微球的修饰方法和效果。文献筛选流程,见图2。
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文题释义:
聚乳酸-羟基乙酸共聚物:由乳酸和羟基乙酸两种单体按不同比例随机聚合而成,这种人工合成的聚合物具有生物相容性、降解性、无毒、成囊和成膜等优点,被广泛应用于生物医用工程、制药及现代化工业领域。该综述从聚乳酸-羟基乙酸共聚物(PLGA)的理化性质出发,介绍其对所制备微球载药能力及药物释放的影响。接着总结归纳微球常用的制备方法,并指出不同方法的优缺点。最后着重介绍PLGA微球作为载体以不同的形式应用于骨组织工程,包括负载生长因子和药物、混入无机矿物或者赋予其调控细胞能力的功能化修饰,以及将PLGA微球与其他支架结合,提供更多功能,弥补微球自身缺陷,从而提高支架整体性能,更好的满足骨组织工程的要求。为PLGA微球的在骨组织工程中的进一步应用提供指导。
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