BACKGROUND: Reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC-allo-HSCT) is proved being one of the effective methods to cure hematologic malignancies recently, which has been used more and more in patients with matched sibling or matched unrelated donor year by year. It is more suitable for elderly patients or younger patients combined with any organ dysfunction or complications. However, matched sibling and matched unrelated donors are not easy to be obtained for RIC-allo-HSCT. While HLA-haploidentical donor can be quickly found in family members for the patients who need receiving RIC-allo-HSCT. Fewer papers for reduced-intensity conditioning haploidentical hematopoietic stem cell transplantation (RIC-haplo-HSCT) have been reported in the world, and none in China, so the review for RIC-haplo-HSCT is necessary.
OBJECTIVE: To reveiw the application of RIC-haplo-HSCT and its prospect.
METHODS: Using “nonmyeloablative conditioning, reduced intensity conditioning, HLA-haploidentical, hematopoietic stem cell transplantation” as key words, we retrieved Wanfang, CNKI and PubMed databases, and foreign language search platform (1997-2014) by computer for literatures about RIC-haplo-HSCT. According to the inclusion and exclusion criteria, 25 articles in English were selected for our review ultimately.
RESULTS AND CONCLUSION: This review shows that RIC-allo-HSCT with matched sibling and matched unrelated donor is widely used and has a better result increasingly. RIC-haplo-HSCT is carried out relatively late and less, and its engraftment, infection, transplant-related mortality, graft-versus-host disease, long-term disease-free survival and overall survival in the early period is a bit weak, but overall the situation has been recently improved significantly. Currently RIC-haplo-HSCT is feasible, especially for patients lack of matched sibling donor and matched unrelate donor, and HLA haploidentical donor becomes the most potential source of hematopoietic stem cells. RIC-haplo-HSCT retains strong graft-versus-leukemia effect, and is easy to look for donor, as well as there are sufficient cells for subsequent treatments such as donor lymphocyte infusion, which through a graft-versus-leukemia effect can eliminate the patient’s malignant cells, especially for elderly patients and younger patients combined with any organ dysfunction or complications. However, due to the relative short time to carry out RIC-haplo-HSCT, how to choice optimal RIC regimen and optimal opportunity and how to reduce transplant-related mortality, graft-versus-host disease and relapse rate require further in-depth studies.