Bone marrow mesenchymal stem cell transplantation combined with core decompression and bone grafting in the repair of osteonecrosis of femoral head

doi:10.3969/j.issn.2095-4344.2015.06.011

Abstract

Abstract:

BACKGROUND: Core decompression alone for osteonecrosis of femoral head easily causes fovea of femoral head and collapse of inner microstructure. Therefore, autologous bone is needed for filling and supporting. Moreover, bone marrow stem cell transplantation can decrease the incidence of femoral head collapse.
OBJECTIVE: To discuss the clinical effects of core decompression and bone grafting combined with autotransplantation of bone marrow mesenchymal stem cells for osteonecrosis of femoral head.
METHODS: A total of 33 patients were treated by core decompression and bone grafting combined with autotransplantation of bone marrow mesenchymal stem cells in the Fourth Department of Bone Surgery, Central Hospital Affiliated to Shenyang Medical College in China from December 2012 to May 2013.
RESULTS AND CONCLUSION: After the treatment by core decompression and bone grafting combined with autotransplantation of bone marrow mesenchymal stem cells, Harris hip function score increased and pain disappeared in patients with osteonecrosis of femoral head. They could do various labors. Radiographs or CT examination displayed normal femoral head in 30 hips, accounting for 79%. Pain significantly reduced. Normal or slight limp walking was found in 15 hips, accounting for 40%. There were 35 hips in patients, whose walking distance was extended, accounting for 92%. 24 hips dysfunction was improved markedly, accounting for 63%. All results suggested that core decompression and bone grafting combined with autotransplantation of bone marrow mesenchymal stem cells improved the local blood supply of femoral head, and played a positive role in promoting the necrotic bone absorption and bone repairing.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

Key words: Femur Head Necrosis, Decompression, Mesenchymal Stem Cell Transplantation, Femur Head

CLC Number:

R394.2

Zhang Yang, Wang Nan, Yang Li-feng, Ma Ji, Li Zhi. Bone marrow mesenchymal stem cell transplantation combined with core decompression and bone grafting in the repair of osteonecrosis of femoral head[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(6): 883-890.

Figures/Tables 4

References

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