Retinal stem cell culture supernatant induces differentiation of bone marrow mesenchymal stem cells

doi:10.3969/j.issn.2095-4344.2013.40.001

Abstract

Abstract:

BACKGROUND: Differentiation of bone marrow mesenchymal stem cells into nerve cells has brought a new hope for the repair and regeneration after nervous system injuries.
OBJECTIVE: To study the neuron-like differentiation of bone marrow mesenchymal stem cells induced by the retinal stem cell culture supernatant.
METHODS: The whole bone marrow culture was applied. The differentiation results of bone marrow mesenchymal stem cells induced by retinal stem cell culture supernatants were identified by immunofluorescence method.
RESULTS AND CONCLUSION: After 72 hours of induction, bone marrow mesenchymal stem cells express nestin and microtubule-associated protein 2. Retinal stem cell culture supernatant can promote bone marrow mesenchymal stem cells differentiating into neuron-like cells, suggesting that retinal stem cells may secrete nerve growth factor.

Key words: stem cells, mesenchymal stem cells, neural stem cells, retina, cell differentiation, microtubule proteins

CLC Number:

R394.2

Wang Zhuo, Wang Dan, Hao Dong-hai, Li Bo. Retinal stem cell culture supernatant induces differentiation of bone marrow mesenchymal stem cells[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(40): 7027-7027.

Figures/Tables 7

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