Chinese Journal of Tissue Engineering Research ›› 2019, Vol. 23 ›› Issue (11): 1781-1787.doi: 10.3969/j.issn.2095-4344.1115

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Mechanism of aerobic exercise improving chronic heart failure by irisin

Wu Jiangbo1,2,Xie Anqing3,Zhang Yong2   

  1.  (1Sport Science College, Beijing Sport University, Beijing 100084, China; 2Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Tianjin University of Sport, Tianjin 301617, China; 3Graduate School, Tianjin University of Sport, Tianjin 301617, China)
  • Received:2018-11-22 Online:2019-04-18 Published:2021-04-28
  • Contact: Zhang Yong, MD, Professor, Doctoral supervisor, Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Tianjin University of Sport, Tianjin 301617, China
  • About author:Wu Jiangbo, Doctoral candidate, Assistant researcher, Sport Science College, Beijing Sport University, Beijing 100084, China; Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Tianjin University of Sport, Tianjin 301617, China
  • Supported by:

    the National Natural Science Foundation of China, No.81370454 (to ZY); the Key Project of Tianjin Application Foundation and Frontier Technology Research Program, No. 14JCZDJC36600 (to ZY); the Youth Project of Tianjin Natural Science Foundation, No. 18JCQNJC12400 (to WJB)

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Abstract:

BACKGROUND: Chronic heart failure is closely related to the homeostasis of myocardial mitochondria and disorders of myocardial energy metabolism. As a proton pump on the membrane of mitochondria, uncoupling protein 2 is closely related to myocardial oxidative stress, energy metabolism and cardiomyocyte apoptosis. It plays an extremely important part in the pathophysiological process of myocardium.
OBJECTIVE: To review the effects of irisin on chronic heart failure and explore the mechanism of aerobic exercise improving chronic heart failure by irisin.
METHODS: A computer-based retrieval of PubMed and CNKI databases was performed to search relevant articles concerning irisin and chronic heart failure published from 2001 to 2018, using the keywords “aerobic exercise, irisin, chronic heart failure” in English and Chinese, respectively. After removal of repetitive and irrelevant articles, 53 eligible articles were finally reviewed, including 45 English and 8 Chinese articles.
RESULTS AND CONCLUSION: Irisin may inhibit the production of reactive oxygen species and simulate the good benefits of aerobic exercise. Irisin plays an important role in aerobic exercise improving chronic heart failure and serves as a potential target for exercise therapy for heart failure. Long-term aerobic exercise may improve heart failure through the irisin/reactive oxygen species/uncoupling protein 2 pathway.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Heart Failure, Oxidative Stress, Mitochondria, Heart, Tissue Engineering

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