Chinese Journal of Tissue Engineering Research ›› 2019, Vol. 23 ›› Issue (11): 1767-1773.doi: 10.3969/j.issn.2095-4344.1104

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Causes, assessment and treatment strategies of sarcopenia in older adults

Wang Kun1,2,Luo Jiong1,2,Liu Li1,2,Ouyang Yiyi1,2   

  1. (1College of Physical Education, Southwest University, State Key Laboratory of Physical Fitness Evaluation and Sports Function Monitoring, Chongqing 400715, China; 2Institute for Sports Rehabilitation of Southwest University, Chongqing 400715, China)
  • Received:2018-10-07 Online:2019-04-18 Published:2021-04-28
  • Contact: Luo Jiong, PhD, Professor, College of Physical Education, Southwest University, State Key Laboratory of Physical Fitness Evaluation and Sports Function Monitoring, Chongqing 400715, China; Institute for Sports Rehabilitation of Southwest University, Chongqing 400715, China
  • About author:Wang Kun, Master candidate, College of Physical Education, Southwest University, State Key Laboratory of Physical Fitness Evaluation and Sports Function Monitoring, Chongqing 400715, China; Institute for Sports Rehabilitation of Southwest University, Chongqing 400715, China
  • Supported by:

    the Basic Research Fund of the Central University of Southwest University, No. SWU1809221 (to LL)

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Abstract:

BACKGROUND: With the development of the aging trend of the population, the incidence of sarcopenia in older adults has obviously increased all over the world. As one of the countries with more serious aging, a unified understanding of sarcopenia has not yet formed in China.
OBJECTIVE: To systematically review the research on senile sarcopenia by domestic and foreign scholars, and to further reveal its etiological mechanism, adverse influential factors and treatment strategies, so as to provide theoretical and practical reference for the effective prevention, mitigation and treatment of sarcopenia.
METHODS: A retrieval of Elsevier SDOL, PubMed, Ovid Medline and CNKI databases was conducted for the literature regarding sarcopenia and aging published before May, 2018. The literature screen was performed based on inclusion criteria.
RESULTS AND CONCLUSION: The prevalence of sarcopenia, as a chronic age-related disease, is closely related to the aging of population. Although its pathogenesis is complex, aging, lack of physical activity, nutrition deficiency, hormone secretion and disease are the inducing factors of sarcopenia. Sarcopenia may lead to cardiovascular disease and metabolic syndrome in the older adults, and reduce the living comfort, hindering the normal physiological activities and even resulting in disability or death. Sarcopenia is often evaluated using the standard of European Working Group on Sarcopenia in Older People and Asian Working Group for Sarcopenia from the perspectives of muscle volume, muscle strength and physiological performance. The evaluation method of Asian Working Group for Sarcopenia is more suitable for the structural characteristics of Asian muscles. There is no drug that can be used to cure senile sarcopenia. The better treatment method is to enhance the muscle volume, muscle strength and muscle function of the older adults through physical exercise, with resistance exercise combined with aerobic exercise to reduce the incidence of senile sarcopenia. While the intake of protein and vitamin D is critical for reducing the loss of muscle and activating muscle strength and function of older adults.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Sarcopenia, Aging Factors, Physical Education and Training, Tissue Engineering

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