Chinese Journal of Tissue Engineering Research ›› 2013, Vol. 17 ›› Issue (25): 4570-4576.doi: 10.3969/j.issn.2095-4344.2013.25.002

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Endosseous implantation of calcium phosphate coated titanium implant prepared via micro-arc oxidation/electrochemical deposition  

Ma Ying1, Meng Xiang-cai2, Wang Jing2, Li De-chao1   

  1. 1 Stomatology Hospital, Jiamusi University, Jiamusi  154002, Heilongjiang Province, China
    2 Jiamusi University, Jiamusi  154007, Heilongjiang Province, China
  • Received:2012-12-19 Revised:2013-01-23 Online:2013-06-18 Published:2013-06-18
  • Contact: Li De-chao, M.D., Associate professor, Stomatology Hospital, Jiamusi University, Jiamusi 154002, Heilongjiang Province, China dechaoli2004@yahoo.com.cn
  • About author:Ma Ying★, Studying for master’s degree, Stomatology Hospital, Jiamusi University, Jiamusi 154002, Heilongjiang Province, China maying6666@yeah.net
  • Supported by:

    the Key Project of Jiamusi University, No. SZ 2009-001

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Abstract:

BACKGROUND: There are studies concerning material properties of coating prepared by micro-arc oxidation and electrochemical deposition, but there are few studies addressing properties of this kind of material implanted in the body.
OBJECTIVE: To observe the synostosis and new bone formation of the pure titanium implant prepared by micro-arc oxidation/electrochemical deposition.
METHODS: This research produces calcium and phosphate coatings on pure titanium though micro-arc oxidation/Electrochemical deposition technology, and the sheep were implanted with micro arc-oxidation/electrochemical deposition implant and pure titanium implant on both sides of the tibia planting socket. All the animals were injected with tetracycline at 15 and 5 days before sacrificing. Radiograph, scanning electron microscope and the laser scanning confocal microscope were used at 4 and 12 weeks post-implantation.
RESULTS AND CONCLUSION: The radiograph shows that there was no shade produced around the two kinds of different materials. The trabeculae arrangement and the density of bone were almost the same as in the host bone. There was interspace between two groups of implant and bone tissue under the scanning electron microscope at 4 weeks post-implantation, and synostosis existed. At 12 weeks post-implantation, the implant prepared by micro-arc oxidation/electrochemical deposition promoted the formation of new bone. Moreover, new bone and implant combined with the original bone tissue closely and there was no obvious gap between the coating and the titanium matrix. The new bone formation was visible in the pure titanium implant group at 12 weeks post-implantation, but the obvious crack was observed. The laser scanning confocal microscopy revealed that the double marking the distance between the belts and the bone mineralization deposition rate in the implant prepared by micro-arc oxidation/electrochemical deposition were higher than that in the pure titanium implant group (P < 0.05). These results indicated that micro-arc oxidation/electrochemical deposition can enhance the synostosis ability and promote the new bone formation of pure titanium implant.

Key words: biomaterials, tissue-engineered bone materials, micro-arc oxidation, pure titanium implant, electrochemical deposition, coating, double labeling, synosteosis, other grants-suported paper

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