Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (22): 3558-3564.doi: 10.3969/j.issn.2095-4344.3183

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Effects of drug coating on implant surface on the osseointegration

Huo Hua1, Cheng Yuting1, Zhou Qian1, Qi Yuhan1, Wu Chao1, Shi Qianhui1, Yang Tongjing1, Liao Jian1, Hong Wei2   

  1. 1School of Stomatology/Stomatological Hospital of Guizhou Medical University, Guiyang 550004, Guizhou Province, China; 2Key Laboratory of Molecular Biology, Guizhou Medical University, Guiyang 550004, Guizhou Province, China
  • Received:2020-07-07 Revised:2020-07-11 Accepted:2020-08-07 Online:2021-08-08 Published:2021-01-20
  • Contact: Liao Jian, MD, Associate professor, Associate chief physician, Master’s supervisor, School of Stomatology/Stomatological Hospital of Guizhou Medical University, Guiyang 550004, Guizhou Province, China
  • About author:Huo Hua, Master candidate, School of Stomatology/Stomatological Hospital of Guizhou Medical University, Guiyang 550004, Guizhou Province, China
  • Supported by:
    the National Natural Science Foundation of China, No. 81660179 (to LJ); the Science and Technology Program of Guizhou Province, No. LH[2016]7257 (to LJ)

Abstract: BACKGROUND: Drug coating on implant surface can effectively enhance dental implant osseointegration and reduce the difficulty of implant restoration.
OBJECTIVE: To review the effects of different drug coating on implant surface on osseointegration.  
METHODS: The first author searched PubMed, VIP, Wanfang and CNKI databases for relevant articles published from January 1986 to July 2020. The search terms were “implant, osseointegration, surface coatings, systemic drugs, carrier” in English and Chinese, respectively. Finally, 67 articles were included in result analysis after screening and summarizing.
RESULTS AND CONCLUSION: Drug coating on the surface of dental implants can promote the local release of bone binding of dental implants through the carrier, and significantly enhance osseointegration intensity and success rate and maximum load of implant, especially reducing the risk of implantation failures rates by osteoporosis. However, we need to solve some problems before this new coating technical is applied to the clinic: the reliability of the combination of carrier materials and drugs, drug release rate and release amount difficult to control, high initial sustained release concentration of local target tissue and difficult to maintain long-term stability and biocompatibility after implantation. Therefore, in the face of the complex oral microenvironment, as well as the influence of many factors of the patient’s physical condition, it needs to be further verified in clinical trials in the later stage, so as to play a positive role of drug coating technology in the field of oral implantation.

Key words: materials, implants, dental implants, drug loading materials, systemic drugs, coating, osseointegration, osteoclasts, osteoblasts, review

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