Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (21): 3382-3389.doi: 10.3969/j.issn.2095-4344.3871
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Pan Xuan1, Zhao Meng2, Zhang Xiumei2, 3, Zhao Jie4, Zhai Yunkai5
Received:
2020-10-14
Revised:
2020-10-15
Accepted:
2020-11-21
Online:
2021-07-28
Published:
2021-01-23
Contact:
Zhang Xiumei, MD, Researcher, Wanfang Data Co., Ltd., Beijing 100036, China; Institute of Scientific and Technical Information of China, Beijing 100036, China
About author:
Pan Xuan, PhD, Assistant researcher, Institutes of Science and Development, Chinese Academy of Sciences, Beijing 100190, China
Supported by:
CLC Number:
Pan Xuan, Zhao Meng, Zhang Xiumei, Zhao Jie, Zhai Yunkai. Research and application of biological three-dimensional printing technology in the field of precision medicine: analysis of Chinese and English literature[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(21): 3382-3389.
2.1 检索结果 最终万方数据库检索到3 111篇中文文献,ISI Web of Science数据库检索到6 941篇英文文献。按照文献类型分类,中文文献分别有期刊论文2 852篇、会议论文259篇,而英文文献分别有期刊论文5 207篇、综述792篇、会议摘要616篇、论文集829篇、观点材料188篇、图书节选152篇,其中,该领域的期刊论文和研究综述占全部英文文献的86.4%。 2.2 文献量发表年份分布及趋势变化 表1可见,相关研究在2016年发文量快速增长至846篇,是2015年的1.5倍,这与《Bioprinting》《International Journal of Bioprinting》等生物3D打印专业学术期刊在这一年陆续出现有关,也意味着该领域的相关研究持续升温且具有广阔的应用前景。此外,发文量的快速增长趋势一直持续(2020年统计数据截至2020年8月,为不完全统计),被引频次和篇均被引频次自2015年以来一直保持较高的增长速率,反映出该领域仍是目前科研热点领域,且存在较多的高质量论文。另外,能较准确反映学术成就的h因子自2015年起保持较高水平,2015年和2016年h因子为83,达到峰值,说明这2年发表的生物3D打印技术相关论文具有较高影响力。"
2.3 文献发表国家和地区 由发文量和被引频次分析可知,近5年来生物3D打印技术相关研究出现爆发式增长,对2015至2020年文献发表国家和地区分布进行统计和分析,发现共有53个国家/地区发表了相关论文。其中美国位居全球第1位,发表文献数量为35 021篇;中国以16 647篇的发文量位居第2位,h因子为56也位居第2位,这反映出中国科研人员在这一领域取得了具有一定影响力的学术成就,但篇均被引频次不高仅排名第9位,说明整体研究水平和文章质量还有待提高;英国和韩国分别发文508和448篇,篇均被引频次和h因子也都比较高,说明这2个国家在该领域的科技研究较活跃,学术研究水平较高。尽管澳大利亚和新加坡近5年的文献发表数量排名分别为第7和9名,但其篇均被引频次和h因子都排名靠前,说明这2个国家产出论文的影响力大,科学成就较高,见图2和表2。 "
2.4 研究机构 图4和表3可见,近5年全球发表论文最多的研究机构是美国加州大学体系(University of California System),共发表163篇论文;哈佛大学(Harvard University)虽然以发文量142篇位居第2位,但是其被引频次、篇均被引频次、h因子均位居第1位,且具有明显优势,说明其在全球生物3D打印领域中处于引领地位,在相关研究机构中具有最高的研究水平和最大的影响力。中国科学院、上海交通大学、浙江大学和清华大学这4家机构也是发文量居前10名的研究机构,这使得中国成为拥有发文量前10名的研究机构最多的国家,说明近5年来中国科研机构和大学在生物3D打印应用于精准医学领域的研究水平发展较快。新加坡南洋理工大学的发文量虽然排在第7位,但其篇均被引频次和h因子均位居第2位,这反映出其具有较高论文质量和学术成就。根据万方数据库发文量显示,近5年中国发文数量排名前5位的高校/研究机构分别是上海交通大学(96篇)、南方医科大学(42篇)、北京大学第三医院(38篇)、西安交通大学(35篇)、解放军总医院和第四军医大学(均各为30篇)。 基于ISI Web of Science英文文献数据检索结果,利用VOSviewer工具分析得到大学/研究机构在生物3D打印领域的合作网络。图5显示在全球范围,美国加州大学体系(University of California System)展现出最广泛的合作互动,其合作比较紧密大学主要包括伦敦大学学院、哈佛大学、浙江大学、四川大学等;其次,哈佛大学与麻省理工学院以及韩国建国大学也保持着密切的合作;中国科学院、浙江大学、上海交通大学与国内外多所大学和研究机构也保持着广泛而紧密的合作关系。不难发现,近5年来这些在全球范围具有广泛合作性的大学和研究机构其中大多数发文数量也位居前列,可见在生物3D打印领域加强科研人员的国际学术交流与合作有助于提高学术产出。 "
创刊于2016年的《Biofabrication》是发表论文最多的期刊,其发文量达185篇,其被引频次和h因子均位居第1位,仅4年时间就成为相关领域最具影响力的期刊,也反映出近年来生物3D打印技术引起了科技界的高度关注。其中,《International Journal of Pharmaceutics》尽管近5年发文量仅为80篇,但其篇均被引频次位居第1位,被引频次和h因子均位居第3位,说明该期刊的发文质量和影响力具有较高水平,且生物3D打印技术在制药、药剂学方面具有应用前景。 万方数据库检索结果中显示近5年发文数量排名前5位的期刊分别是《中国组织工程研究》132篇、《中华创伤骨科杂志》52篇、《中国骨与关节损伤杂志》46篇、《中国修复重建外科杂志》39篇、《中国矫形外科杂志》33篇。 2.6 高频关键词分布 通过提取ISI Web of Science英文文献检索结果中的关键词,并进行大数据分析和统计后对其中的高频关键词进行可视化展现,可以得出在全球范围生物3D打印技术在精准医学中的研究热点主要包括生物墨水、微流控、矫形外科、组织/器官再生、药物研发等,见图6。 "
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