Research and application of biological three-dimensional printing technology in the field of precision medicine: analysis of Chinese and English literature

doi:10.3969/j.issn.2095-4344.3871

Abstract

Abstract: BACKGROUND: Biological three-dimensional (3D) printing technology has been extensively utilized in numerous fields of biomedicine. However, not many cases have been successfully transformed into clinical trials. It is still in the development stage in precision medicine. This technology reveals great potential in realizing individualized medical treatment, changing the existing treatment process, and helping pharmaceutical and medical companies develop more accurate drugs. Furthermore, it is expected to accomplish the closed-loop from individualized information collection and diagnosis to individualized medical product preparation and precise treatment scheme.
OBJECTIVE: To analyze the current research and hotspots of biological 3D printing technology in precision medicine.
METHODS: Web of Science and Wanfang databases were searched for literature on 3D printing technology in precision medicine published from January 2015 to August 2020. The retrieval results received scientific quantitative analysis through big data analysis tools, mathematical statistics, computer semantic analysis, visualization software, and database analysis and retrieval.
RESULTS AND CONCLUSION: (1) The amount of studies on 3D printing technology in the field of precision medicine gradually increases from 2015 to 2020. (2) The United States has the largest amount of publications, and its cooperation with other countries also occupies a core position. The research in China is also active in this field. (3) The institution that published the most papers in the world in the past five years is the University of California system, while the Chinese Academy of Sciences and Shanghai Jiao Tong University are the Chinese institutions with the highest number of publications. (4) Biofabrication and Chinese Journal of Tissue Engineering Research are the journals with the largest number of publications in the world and in China, respectively. (5) The hotspots of biological 3D printing technology in precision medicine mainly include bioinks, microfluidics, orthopedics, tissue/organ regeneration, and drug development. The research results published in Chinese journals are mainly concentrated in the fields of orthopedics, tissue engineering, clinical teaching, and medical models. (6) As one of the most revolutionary and influential advanced tools, biological 3D printing has achieved some accomplishments in regenerative medicine and organ transplantation. It has become an excellent scientific research tool in tissue engineering, stem cells, and cancer, and has created a way for precision medicine from medical imaging, preoperative plan to implant design and manufacture through digital tools.

Key words: precision medicine, regenerative medicine, biological 3D printing, additive manufacturing, visualization analysis, bioinks, microfluidics, orthopedics, tissue/organ regeneration, drug development

CLC Number:

Pan Xuan, Zhao Meng, Zhang Xiumei, Zhao Jie, Zhai Yunkai. Research and application of biological three-dimensional printing technology in the field of precision medicine: analysis of Chinese and English literature[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(21): 3382-3389.

Figures/Tables 10

2.4 研究机构图4和表3可见，近5年全球发表论文最多的研究机构是美国加州大学体系(University of California System)，共发表163篇论文；哈佛大学(Harvard University)虽然以发文量142篇位居第2位，但是其被引频次、篇均被引频次、h因子均位居第1位，且具有明显优势，说明其在全球生物3D打印领域中处于引领地位，在相关研究机构中具有最高的研究水平和最大的影响力。中国科学院、上海交通大学、浙江大学和清华大学这4家机构也是发文量居前10名的研究机构，这使得中国成为拥有发文量前10名的研究机构最多的国家，说明近5年来中国科研机构和大学在生物3D打印应用于精准医学领域的研究水平发展较快。新加坡南洋理工大学的发文量虽然排在第7位，但其篇均被引频次和h因子均位居第2位，这反映出其具有较高论文质量和学术成就。根据万方数据库发文量显示，近5年中国发文数量排名前5位的高校/研究机构分别是上海交通大学(96篇)、南方医科大学(42篇)、北京大学第三医院(38篇)、西安交通大学(35篇)、解放军总医院和第四军医大学（均各为30篇)。基于ISI Web of Science英文文献数据检索结果，利用VOSviewer工具分析得到大学/研究机构在生物3D打印领域的合作网络。图5显示在全球范围，美国加州大学体系(University of California System)展现出最广泛的合作互动，其合作比较紧密大学主要包括伦敦大学学院、哈佛大学、浙江大学、四川大学等；其次，哈佛大学与麻省理工学院以及韩国建国大学也保持着密切的合作；中国科学院、浙江大学、上海交通大学与国内外多所大学和研究机构也保持着广泛而紧密的合作关系。不难发现，近5年来这些在全球范围具有广泛合作性的大学和研究机构其中大多数发文数量也位居前列，可见在生物3D打印领域加强科研人员的国际学术交流与合作有助于提高学术产出。 "

References

[1] NGO TD, KASHANI A, IMBALZANO G, et al. Additive manufacturing (3D printing): A review of materials, methods, applications and challenges. Compos B Eng. 2018;143:172-196.
[2] MARTIN JH, YAHATA BD, HUNDLEY JM, et al. 3D printing of high-strength aluminium alloys. Nature. 2017;549(7672):365-369.
[3] LIGON SC, LISKA R, STAMPFL J, et al. Polymers for 3D Printing and Customized Additive Manufacturing. Chem Rev. 2017;117(15): 10212-10290.
[4] ZAREK M, LAYANI M, COOPERSTEIN I, et al. 3D Printing of Shape Memory Polymers for Flexible Electronic Devices. Adv Mater. 2016; 28(22):4449-4454.
[5] WAHEED S, CABOT JM, MACDONALD NP, et al. 3D printed microfluidic devices: enablers and barriers. Lab Chip. 2016;16(11):1993-2013.
[6] LEE JY, AN J, CHUA CK. Fundamentals and applications of 3D printing for novel materials. Applied Materials Today. 2017;7:120-133.
[7] CHIMENE D, LENNOX KK, KAUNAS RR, et al. Advanced Bioinks for 3D Printing: A Materials Science Perspective. Ann Biomed Eng. 2016;44(6): 2090-2102.
[8] VADODARIA S, MILLS T. Jetting-based 3D printing of edible materials. Food Hydrocolloids. 2020;106:105857.
[9] WELCH JL, XIANG J, MACKIN SR, et al. Inactivation of Severe Acute Respiratory Coronavirus Virus 2 (SARS-CoV-2) and Diverse RNA and DNA Viruses on Three-Dimensionally Printed Surgical Mask Materials. Infect Control Hosp Epidemiol. 2020. doi:10.1017/ice.2020.417.
[10] KOTZ F, HELMER D, RAPP BE. Emerging Technologies and Materials for High-Resolution 3D Printing of Microfluidic Chips. Adv Biochem Eng Biotechnol. 2020. doi: 10.1007/10_2020_141.
[11] ZHANG Y, ZHANG F, YAN Z, et al. Printing, folding and assembly methods for forming 3D mesostructures in advanced materials. Nat Rev Mater. 2017;2(4):17019.
[12] HE R, LIU W, WU Z, et al. Fabrication of complex-shaped zirconia ceramic parts via a DLP- stereolithography-based 3D printing method. Ceram Int. 2018;44(3):3412-3416.
[13] BAGHERI SAED A, BEHRAVESH AH, HASANNIA S, et al. Functionalized poly l-lactic acid synthesis and optimization of process parameters for 3D printing of porous scaffolds via digital light processing (DLP) method. J Manuf Process. 2020;56:550-561.
[14] 张秀梅,翟运开,丁楠,等.精准医学决策支持知识组织研究[J].医学信息学杂志,2020,41(5):24-29,48.
[15] 赵晓宇,刁天喜,高云华,等.美国“精准医学计划”解读与思考[J].军事医学,2015(4):241-244.
[16] SAUNDERS RE, DERBY B. Inkjet printing biomaterials for tissue engineering: bioprinting. Inter Mater Rev. 2014;59(8):430-448.
[17] HEINRICH MA, LIU W, JIMENEZ A, et al. 3D Bioprinting: from Benches to Translational Applications. Small. 2019;15(23):e1805510.
[18] WU C, WANG B, ZHANG C, et al. Bioprinting: an assessment based on manufacturing readiness levels. Crit Rev Biotechnol. 2017;37(3): 333-354.
[19] JAMRÓZ W, SZAFRANIEC J, KUREK M, et al. 3D Printing in Pharmaceutical and Medical Applications - Recent Achievements and Challenges. Pharm Res. 2018;35(9):176.
[20] CUI H, NOWICKI M, FISHER JP, et al. 3D Bioprinting for Organ Regeneration. Adv Healthc Mater. 2017;6(1):10.1002/adhm.201601118.
[21] BIAZAR E, NAJAFI SM, HEIDARI KS, et al. 3D bio-printing technology for body tissues and organs regeneration. J Med Eng Technol. 2018;42(3): 187-202.
[22] AIMAR A, PALERMO A, INNOCENTI B. The Role of 3D Printing in Medical Applications: A State of the Art. J Healthc Eng. 2019;2019:5340616.
[23] HOSPODIUK M, DEY M, SOSNOSKI D, et al. The bioink: A comprehensive review on bioprintable materials. Biotechnol Adv. 2017;35(2):217-239.
[24] HÖLZL K, LIN S, TYTGAT L, et al. Bioink properties before, during and after 3D bioprinting. Biofabrication. 2016;8(3):032002.
[25] RASTOGI P, KANDASUBRAMANIAN B. Review of alginate-based hydrogel bioprinting for application in tissue engineering. Biofabrication. 2019; 11(4):042001.
[26] VALOT L, MARTINEZ J, MEHDI A, et al. Chemical insights into bioinks for 3D printing. Chem Soc Rev. 2019;48(15):4049-4086.
[27] ARRIGONI C, GILARDI M, BERSINI S, et al. Bioprinting and Organ-on-Chip Applications Towards Personalized Medicine for Bone Diseases. Stem Cell Rev Rep. 2017;13(3):407-417.
[28] GOLD K, GAHARWAR AK, JAIN A. Emerging trends in multiscale modeling of vascular pathophysiology: Organ-on-a-chip and 3D printing. Biomaterials. 2019;196:2-17.
[29] YU F, CHOUDHURY D. Microfluidic bioprinting for organ-on-a-chip models. Drug Discov Today. 2019;24(6):1248-1257.
[30] MI S, DU Z, XU Y, et al. The crossing and integration between microfluidic technology and 3D printing for organ-on-chips. J Mater Chem B. 2018;6(39):6191-6206.
[31] BHATTACHARJEE N, URRIOS A, KANG S, et al. The upcoming 3D-printing revolution in microfluidics. Lab Chip. 2016;16(10):1720-1742.
[32] RADHAKRISHNAN J, VARADARAJ S, DASH SK, et al. Organotypic cancer tissue models for drug screening: 3D constructs, bioprinting and microfluidic chips. Drug Discov Today. 2020;25(5):879-890.
[33] RICHARD C, NEILD A, CADARSO VJ. The emerging role of microfluidics in multi-material 3D bioprinting. Lab Chip. 2020;20(12):2044-2056.
[34] SANTANA HS, PALMA MSA, LOPES MGM, et al. Microfluidic Devices and 3D Printing for Synthesis and Screening of Drugs and Tissue Engineering. Ind Eng Chem Res. 2020;59(9):3794-3810.
[35] SKELLEY NW, HAGERTY MP, STANNARD JT, et al. Sterility of 3D-Printed Orthopedic Implants Using Fused Deposition Modeling. Orthopedics. 2020;43(1):46-51.
[36] FRIZZIERO L, LIVERANI A, DONNICI G, et al. New Methodology for Diagnosis of Orthopedic Diseases through Additive Manufacturing Models. Symmetry. 2019;11(4):27.
[37] DONG XP, ZHANG YW, PEI YJ, et al. Three-dimensional printing for the accurate orthopedics: clinical cases analysis. Biodes Manuf. 2020;3(2): 122-132.
[38] BRUNS N, KRETTEK C. 3D-printing in trauma surgery : Planning, printing and processing. Unfallchirurg. 2019;122(4):270-277.
[39] ALLEN B, MOORE C, SEYLER T, et al. Modulating antibiotic release from reservoirs in 3D-printed orthopedic devices to treat periprosthetic joint infection. J Orthop Res. 2020;38(10):2239-2249.
[40] HAN C, YAO Y, CHENG X, et al. Electrophoretic Deposition of Gentamicin-Loaded Silk Fibroin Coatings on 3D-Printed Porous Cobalt-Chromium-Molybdenum Bone Substitutes to Prevent Orthopedic Implant Infections. Biomacromolecules. 2017;18(11):3776-3787.
[41] VIJAYAVENKATARAMAN S, GOPINATH A, LU WF. A new design of 3D-printed orthopedic bone plates with auxetic structures to mitigate stress shielding and improve intra-operative bending. Biodes Manuf. 2020;3(2):98-108.
[42] 朱浩,郑孟杰,李延超,等.3D打印技术在颧上颌复合体骨折治疗中应用[J].创伤与急危重病医学,2020,8(5):335-337.
[43] 凌昊楠,李松军.3D打印复合支架修复软骨缺损的研究进展[J].医学综述,2020,26(18):3572-3576,3582.
[44] 李焕龙,耿承奎,陈帅,等.3D打印技术在骨盆手术中的应用[J].实用医学杂志,2020,36(17):2329-2333.
[45] 唐保明,李钊伟,杨爱荣,等.3D打印技术辅助治疗复杂髋臼骨折的疗效研究[J].中国医学装备,2020,17(9):107-110.
[46] 刘婷,杨德雨,刘莉,等.3D打印技术在脑血管病中的应用进展[J].中国卒中杂志,2020,15(8):916-920.
[47] CHEN H, HAN Q, WANG C, et al. Porous Scaffold Design for Additive Manufacturing in Orthopedics: A Review. Front Bioeng Biotechnol. 2020;8:609.
[48] BARTOLOMEU F, DOURADO N, PEREIRA F, et al. Additive manufactured porous biomaterials targeting orthopedic implants: A suitable combination of mechanical, physical and topological properties. Mater Sci Eng C Mater Biol Appl. 2020;107:110342.
[49] GAO CH, WANG CY, JIN H, et al. Additive manufacturing technique-designed metallic porous implants for clinical application in orthopedics. RSC Adv. 2018;8(44):25210-25227.
[50] HAN X, YANG D, YANG C, et al. Carbon Fiber Reinforced PEEK Composites Based on 3D-Printing Technology for Orthopedic and Dental Applications. J Clin Med. 2019;8(2):240.
[51] BOSE S, BANERJEE D, SHIVARAM A, et al. Calcium phosphate coated 3D printed porous titanium with nanoscale surface modification for orthopedic and dental applications. Mater Des. 2018;151:102-112.
[52] NARITA M, TAKAKI T, SHIBAHARA T, et aI. Utilization of desktop 3D printer-fabricated “Cost-Effective” 3D models in orthognathic surgery. Maxillofac Plast Reconstr Surg. 2020;42(1):24.
[53] LOUVRIER A, MARTY P, BARRABÉ A, et al. How useful is 3D printing in maxillofacial surgery?. J Stomatol Oral Maxillofac Surg. 2017;118(4):206-212.
[54] DATTA P, AYAN B, OZBOLAT IT. Bioprinting for vascular and vascularized tissue biofabrication. Acta Biomater. 2017;51:1-20.
[55] MONDSCHEIN RJ, KANITKAR A, WILLIAMS CB, et al. Polymer structure-property requirements for stereolithographic 3D printing of soft tissue engineering scaffolds. Biomaterials. 2017;140:170-188.
[56] ALI M, P R AK, LEE SJ, et al. Three-dimensional bioprinting for organ bioengineering: promise and pitfalls. Curr Opin Organ Transplant. 2018;23(6):649-656.
[57] WU Y, RAVNIC DJ, OZBOLAT IT. Intraoperative Bioprinting: Repairing Tissues and Organs in a Surgical Setting. Trends Biotechnol. 2020; 38(6):594-605.
[58] ESWARAMOORTHY SD, RAMAKRISHNA S, RATH SN. Recent advances in three-dimensional bioprinting of stem cells. J Tissue Eng Regen Med. 2019;13(6):908-924.
[59] LEI M, WANG X. Biodegradable Polymers and Stem Cells for Bioprinting. Molecules. 2016;21(5):539.
[60] AXPE E, OYEN ML. Applications of Alginate-Based Bioinks in 3D Bioprinting. Int J Mol Sci. 2016;17(12):1976.
[61] SHANJANI Y, KANG Y, ZARNESCU L, et al. Endothelial pattern formation in hybrid constructs of additive manufactured porous rigid scaffolds and cell-laden hydrogels for orthopedic applications. J Mech Behav Biomed Mater. 2017;65:356-372.
[62] VITHANI K, GOYANES A, JANNIN V, et al. An Overview of 3D Printing Technologies for Soft Materials and Potential Opportunities for Lipid-based Drug Delivery Systems. Pharm Res. 2018;36(1):4.
[63] TRENFIELD SJ, AWAD A, MADLA CM, et al. Shaping the future: recent advances of 3D printing in drug delivery and healthcare. Expert Opin Drug Deliv. 2019;16(10):1081-1094.
[64] MAZZOCCHI A, SOKER S, SKARDAL A. 3D bioprinting for high-throughput screening: Drug screening, disease modeling, and precision medicine applications. Applied Physics Reviews. 2019;6(1):011302.
[65] AFSANA, JAIN V, HAIDER N, et al. 3D Printing in Personalized Drug Delivery. Curr Pharm Des. 2018;24(42):5062-5071.
[66] GOOLE J, AMIGHI K. 3D printing in pharmaceutics: A new tool for designing customized drug delivery systems. Int J Pharm. 2016;499(1-2): 376-394.
[67] YAN WC, DAVOODI P, VIJAYAVENKATARAMAN S, et al. 3D bioprinting of skin tissue: From pre-processing to final product evaluation. Adv Drug Deliv Rev. 2018;132:270-295.
[68] MA X, LIU J, ZHU W, et al. 3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling. Adv Drug Deliv Rev. 2018;132:235-251.
[69] 赵莹莹.3D打印技术在药物发展中的应用[J].河南科技,2020,(17): 70-71.
[70] 孙冲,刘堂义.3D打印技术在医学中的应用[J].中医学,2019,8(3): 197-202.
[71] 陈绍华,徐浩,王拥军,等.3D生物打印药物筛选生理病理模型平台建立的研究进展[J].世界科学技术-中医药现代化,2019,21(9): 1902-1908.
[72] 石靖,王增明,郑爱萍.3D打印技术在药物制剂中的应用和挑战[J].药学进展,2019,43(3):164-173.
[73] 马薇.3D打印技术在药物制剂中的研究进展[J].今日药学,2018, 28(3):204-206.
[74] 陈国宁,舒花,余佩,等.3D打印技术在药学领域研究中的应用[J].中国药学杂志,2016,51(16):1353-1359.
[75] 王雪,张灿,平其能.3D打印技术在药物高端制剂中的研究进展[J].中国药科大学学报,2016,47(2):140-147.