Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (5): 761-764.doi: 10.3969/j.issn.2095-4344.3012

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Application of 3D-printed coplanar template combined with fixed needle technique in percutaneous accurate biopsy of small pulmonary nodules

Xu Junma1, Yu Yuechao2, Liu Zhi2, Liu Yu2, Wang Feitong3   

  1. 1Department of Respiratory Medicine, Jintan People’s Hospital, Jiangsu University, Changzhou  213200, Jiangsu Province, China; 2Department of Nuclear Medicine, the Second Affiliated Hospital of Xuzhou Medical University, Xuzhou  221000, Jiangsu Province, China; 3Cancer Center, Xuzhou Medical University, Xuzhou  221000, Jiangsu Province, China
  • Received:2019-08-13 Revised:2019-08-15 Accepted:2020-04-15 Online:2021-02-18 Published:2020-12-01
  • Contact: Wang Feitong, Associate chief physician, Cancer Center, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China
  • About author:Xu Junma, Master, Associate chief physician, Department of Respiratory Medicine, Jintan People’s Hospital, Jiangsu University, Changzhou 213200, Jiangsu Province, China
  • Supported by:
    the Natural Science Foundation of Jiangsu Universities (General Project), No. 17KJD320004

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Abstract: BACKGROUND: Percutaneous lung biopsy is an important method to clarify the nature of lung nodules. However, the lungs are more active due to the presence of respiratory motion. Percutaneous lung biopsy, especially for small lung nodules, is difficult.
OBJECTIVE: To introduce the application of 3D-printed coplanar template combined with fixed needle technique in percutaneous biopsy of small pulmonary nodules.
METHODS: A total of 24 patients who had percutaneous lung biopsy in the Second Affiliated Hospital of Xuzhou Medical University from July 2018 to April 2019 were enrolled. Imaging examination indicated small pulmonary nodules with a nodule diameter of 8-30 mm in all the patients. According to the probability of malignancy, all tumors were of the middle and high risk grade, and there were indications for percutaneous lung biopsy. All the patients were randomized into two groups (n=12 per group): the control group underwent free hand biopsy, and the observation group underwent percutaneous lung biopsy guided by 3D printed coplanar template combined with fixed needle. The number of puncture needle adjustments, number of CT scans, positive rate of specimens, and incidence of complications were recorded and compared between the two groups. Approval for this trial was obtained from the Ethics Committee of the Second Affiliated Hospital of Xuzhou Medical University.
RESULTS AND CONCLUSION: The number of puncture needle adjustments, the number of CT scans and the incidence of pneumothorax during the operation were significantly lower in the observation group than the control group (P < 0.05), whereas there were no significant differences in the positive rate of specimens and incidence of bleeding complications between the two groups (P > 0.05). These findings indicate that the 3D-printed coplanar template combined with fixed needle technique can relatively fix the target lesion, reduce the number of needle adjustments and number of CT scans, reduce iatrogenic radiation, and reduce the incidence of complications, especially pneumothorax.

Key words: 3D printing, coplanar template, fixed needle, lung, lung nodule, biopsy, precision medicine

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