Generation and application of three-dimensional cell traction force

doi:10.3969/j.issn.2095-4344.2017.08.026

Abstract

Abstract:

BACKGROUND: Traction force generated by adherent cells exerts on the extracellular matrix or cell substrate through the interaction between actin and myosin, which involves a variety of physiological and pathological processes.
OBJECTIVE: To review the fundamental principles and application of several traction force techniques.
METHODS: The first author retrieved the databases of CNKI, WanFang, PubMed and SpringerLink for the research addressing the measurements of traction force using the keywords of “cell traction force, biomechanics” in Chinese and English, respectively. Repetitive articles were excluded, and 30 literatures were enrolled for analysis, including 1 Chinese and 29 English articles.
RESULTS AND CONCLUSION: There are three kinds of measurements of traction force, such as silica gel membrane, traction force microscopy, and micromachined levers. The precise measurement of traction force contributes to further understand the cell-cell and cell-microenvironment mechanical interactions.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Cells, Mechanics, Tissue Engineering

CLC Number:

R318

Liu Chen, Chen Wei-yi, Li Xiao-na, Wang Xiao-jun. Generation and application of three-dimensional cell traction force[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(8): 1301-1306.

Figures/Tables 4

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