Chinese Journal of Tissue Engineering Research ›› 2017, Vol. 21 ›› Issue (8): 1306-1312.doi: 10.3969/j.issn.2095-4344.2017.08.027

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Research advancement of tissue engineering in urology

Sun Heng1, Zhao Zhan-kui2, Meng Lin2, Yu Hong-lian1, Kong Qing-sheng1   

  1. 1Jining Medical University, Jining 272100, Shandong Province, China; 2Department of Urology, the Affiliated Hospital of Jining Medical University, Jining 272029, Shandong Province, China
  • Received:2017-01-28 Online:2017-03-18 Published:2017-04-14
  • Contact: Zhao Zhan-kui, M.D., Attending physician, Department of Urology, the Affiliated Hospital of Jining Medical University, Jining 272029, Shandong Province, China
  • About author:Sun Heng, Studying for master’s degree, Jining Medical University, Jining 272100, Shandong Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81500517 and 81402119; the Natural Science Foundation of Shandong Province, No. ZR2014HL071, ZR2013CM031 and ZR2014HP055; the Doctoral Fund of the Affiliated Hospital of Jining Medical University, No. 2016-BS-010

Abstract:

BACKGROUND: Tissue engineering provides a new way for the repair of urinary tissue and organ defects. Urinary tissue engineering has shown a bright prospect.
OBJECTIVE: To review the latest research on urinary tissue engineering at national and international level.
METHODS: With the keywords of “tissue engineering, urology, scaffold, vascularization” in Chinese and in English, respectively, a computer-based search for articles published from January 2000 to January 2016 was performed in CNKI and PubMed databases. The articles addressing urology tissue engineering, scaffolds and vascularization were collected, summarized and analyzed.
RESULTS AND CONCLUSION: The selection and cultivation of seed cells, scaffold material performance, tissue construction in vitro, and degree of vascularization all make an important influence on the repair of urinary injuries. As different seed cells hold different biological characteristics, we should make full consideration prior to choosing an appropriate seed cell, so as to pave a good foundation for urinary tissue engineering. Scaffolds with good three-dimensional structure can promote the cell growth and proliferation, tissue in-growth and vascularization. Tissue-engineered materials are superior to traditional repair materials, but still on initial stage, and further large scale trials will be necessary. Moreover, some problems needed to be solved, such as the regenerated tissue with incomplete function different from natural tissues, and regeneration failure caused by biological stent rejection.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Urologic Surgical Procedures, Cells, Tissue Scaffolds, Neovascularization, Physiologic, Tissue Engineering

CLC Number: