Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (51): 7717-7723.doi: 10.3969/j.issn.2095-4344.2016.51.018

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Bone marrow mesenchymal stem cells differentiate into cartilage and bone: roles of Wnt5a/PCP signaling pathways

Peng Xu1, Zhang Xiao-mei1, Wei Shi-hang2, Liu Yan1, He Xue-ling1   

  1. 1Laboratory Animal Center, Sichuan University, Chengdu 610041, Sichuan Province, China; 2College of Life Science, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2016-09-10 Online:2016-12-09 Published:2016-12-09
  • Contact: Corresponding author: He Xue-ling, M.D., Associate researcher, Laboratory Animal Center, Sichuan University, Chengdu 610041, Sichuan Province, China Corresponding author Liu Yan, Master, Assistant researcher, Laboratory Animal Center, Sichuan University, Chengdu 610041, Sichuan Province, China
  • About author:Peng Xu, Master, Assistant experimentalist, Laboratory Animal Center, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 51573112; the Science and Technology Project of Science & Technology Department of Sichuan Province, No. 2015SZ0075

Abstract:

BACKGROUND: Wnt5a is able to inhibit canonical Wnt signaling and activate non-canonical Wnt signaling pathway. In recent years, it has been found that non-classical Wnt5a/PCP signaling pathway mediated by Wnt5a plays an important role in the process of bone marrow mesenchymal stem cell proliferation and differentiation, but the underlying mechanism is unclear.
OBJECTIVE: To summarize the progress in downstream effector molecules related to Wnt5a/PCP signaling pathway, and its roles in the chondrogenic and osteogenic differentiation of bone marrow mesenchymal stem cells.
METHODS: A computer-based online search of CqVip, CNKI and PubMed databases between January 2000 and February 2016 was performed using the Chinese keywords of “BMSCs, Wnt signaling pathways, chondrogenic differentiation, osteogenic differentiation” and English keywords of “BMSCs, chondrogenic differentiation, osteogenic differentiation, Wnt, Fzd, Ror2, RhoA, ROCK, JNK”, respectively. Literatures related to bone marrow mesenchymal stem cell chondrogenic and osteogenic differentiation were selected. Finally, 43 eligible articles were included for analysis through excluding the old and repeated research.
RESULTS AND CONCLUSION: Wnt5a, a representative protein in non-canonical Wnt signaling pathway, paticipates in the cytoskeleton, cell migration and cell polarization and other activities by mediating its downstream signaling molecules such as Fzd, Ror, RhoA, ROCK, JNK, thereby regulating its proliferation and differentiation. But it is unclear how Wnt5a/PCP participates in the bone marrow mesenchymal stem cell chondrogenic and osteogenic differentiation and how the downstream effector molecules interact or function independently, which requires further studies.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Mesenchymal Stem Cells, Cartilage, Osteogenesis, Tissue Engineering

CLC Number: