Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (46): 6950-6955.doi: 10.3969/j.issn.2095-4344.2016.46.015

Previous Articles     Next Articles

Three-part failure collapse mechanism hypothesis and new concept for preserving hip joint after osteonecrosis of the femoral head

Pang Zhi-hui1, Tang Li-ming2, Fan Yue-guang2, Ge Hui1, Li Peng-fei1, Guo Fu-ming1, He Wei2,
Wang Hai-bin1   

  1. 1Department of Digital Orthopaedic and Biomechanics Laboratory of National Key Discipline Orthopaedic and Traumatology of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; 2National Chinese Medicine Key Specialist of Hip Disease, the First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • Received:2016-08-29 Online:2016-11-11 Published:2016-11-11
  • Contact: Fan Yue-guang, Professor, Doctoral supervisor, National Chinese Medicine Key Specialist of Hip Disease, the First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • About author:Pang Zhi-hui, M.D., Department of Digital Orthopaedic and Biomechanics Laboratory of National Key Discipline Orthopaedic and Traumatology of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • Supported by:

    the Natural Science Foundation of Guangdong Province (General Program), No. S2013010011992; the Natural Science Foundation of Guangdong Province (Doctor Start), No. S2014A030310214; the Science and Technology Project of Guangdong Province, No. (2014)807

Abstract:

BACKGROUND: Unsatisfactory clinical efficacy of hip-preserving treatment after osteonecrosis of the femoral head is unavoidable.
OBJECTIVE: To reveal the collapse mechanism of osteonecrosis of the femoral head, and then point out the direction for improvement.
METHODS: We put up with three-part failure collapse mechanism hypothesis of osteonecrosis of the femoral head for the first time according to a series of studies by our research team in recent 5 years, paralleling with preliminary verification from three aspects of biomechanics, pathology and clinical application.
RESULTS AND CONCLUSION: New concept of maintaining stability and promoting repair for hip preservation and new surgical procedures aiming at the reconstruction of femoral head anterior lateral columns are well presented, and good short-term effects have been achieved. These results show that the mid-long-term clinical curative effect and mechanism of action are worthy of further study.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Femur Head, Hip Joint, Tissue Engineering

CLC Number: