The fibroblast growth factor signaling pathway

doi:10.3969/j.issn.2095-4344.2016.15.018

Abstract

Abstract:

BACKGROUND: In the earliest stages of embryonic development and organ formation, fibroblast growth factor family members function as mediating the growth, differentiation, survival, and morphology of progenitor cells. Fibroblast growth factor mediates metabolic function, tissue repair and regeneration in mature tissues by reactivation of signal pathways.

OBJECTIVE: To summarize and explore the role of the fibroblast growth factor signaling pathway in tissues and organs.

METHODS: A computer-based online search was conducted in CNKI and PubMed databases by using the key words of “fibroblast growth factor, signaling pathway” from 2010 to 2016 and 2000 to 2016, respectively to screen the relevant literatures. The language was limited to both Chinese and English. Research progress in the fibroblast growth factor signaling pathway was summarized.

RESULTS AND CONCLUSION:A total of 47 literatures were included. Mammalian fibroblast growth factor family is composed of 18 secreted signal proteins which interact with 4 tyrosine kinase signal fibroblast growth factor receptors. Interaction of fibroblast growth factor ligand with the receptor is regulated by a protein or cofactor binding proteoglycans and extracellular proteins. Activation of fibroblast growth factor receptor mediates interaction with cytoplasmic adapter protein, RAS-MAPK, and PI3K-AKT, phospholipase Cγ and STAT signaling pathway by phosphorylation on a specific tyrosine residue. Four structurally related intracellular non-signaling fibroblast growth factors regulate the voltage-gated sodium ion channels by their interactions. Fibroblast growth factors exist in almost all tissues and organs, and developmental defects and abnormal activity of this pathway (destruction of organogenesis) is associated with damage response to injury, metabolic disorders and cancer.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Tissue Engineering, Fibroblast Growth Factors, Neoplasms

Su Yu-han, Du Hua, Niu Guang-ming, Wang Jing, Weng Li-xin. The fibroblast growth factor signaling pathway[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(15): 2255-2264.

Figures/Tables 1

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