Hedgehog signal regulates the chondrogenesis from bone marrow mesenchymal stem cells: controlling methods and cross-talking relationship with other signals need further studies

doi:10.3969/j.issn.2095-4344.2014.37.025

Abstract

Abstract:

BACKGROUND: The hedgehog pathway has paid an important role in the progress of chondrogenesis from bone marrow mesenchymal stem cells. However, the definite signal transduction pathway and cross-talking relationship with other common signal pathways are still poorly understood and the researches related to this field is to continue as a hotspot in the future study.
OBJECTIVE: To investigate the research progress of hedgehog signal pathway on the regulation of the chondrogenesis from bone marrow mesenchymal stem cells and the relationship between hedgehog and other signal pathways in the process.
METHODS: A computer-based online search in CNKI, PubMed and Google Scholar databases was performed using key words of “Hedgehog, IHH, SHH, bone marrow mesenchymal stem cells, cartilage, chondrogenesis” in English and Chinese, respectively. Literatures related to the process of chondrogenesis from bone marrow mesenchymal stem cells were included and 36 articles were extensively summarized for review.
RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cells are currently accepted optimal cell seeds for the cartilage tissue engineering, and hedgehog is a critical signal molecule in the development of skeletal system. The IHH and SHH in hedgehog signal closely participate in controlling the processes of bone marrow mesenchymal stem cell proliferation and chondrogenesis, chondrocyte phenotype maintenance and cooperation with other common single pathways. However, the specific signal transduction mechanism and cross-talking contact with other signal pathways still need to be further studied, and it stands for the future research directions.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

Key words: bone marrow, mesenchymal stem cells, cartilage, Hedgehog proteins

CLC Number:

R318

Liu Kuan, Wu Xing. Hedgehog signal regulates the chondrogenesis from bone marrow mesenchymal stem cells: controlling methods and cross-talking relationship with other signals need further studies[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(37): 6040-6045.

Figures/Tables 1

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