Effect of acupuncture of “Xingnao Kaiqiao” on the behavior of an immature rat model of cerebral palsy and the underlying mechanism

doi:10.3969/j.issn.2095-4344.2016.49.003

Abstract

Abstract:

BACKGROUND: Acupuncture of “Xingnao Kaiqiao” can treat cerebral palsy by increasing cerebral blood flow, decreasing inflammatory reaction and promoting cerebral nerve repair.
OBJECTIVE: To explore the influence of acupuncture of “Xingnao Kaiqiao” on behavior of immature rats with cerebral palsy and the underlying mechanism.
METHODS: (1) The immature rat model of cerebral palsy was established and then randomized into control, model and acupuncture groups. (2) The immature rats in the acupuncture group were treated with acupuncture at major points of Neiguan (P 6), Renzhong (Du 26) and Sanyinjiao (Sp 6), as well as auxiliary points of Jiquan (H 1), Chize (Lu 5) and Weizhong (UB 40), while the model and control groups received no intervention. (3) Twenty-four days later, the body mass and the time removing the mackintosh at forepassed center were measured and recorded, the spatial learning and memory ability was detected by Mortis water maze test, and the serum levels of tumor necrosis factor alpha and interleukin-6 were detected by ELISA.
RESULTS AND CONCLUSION: (1) The order of the body mass gained was as follows: control group > acupuncture group > model group (P < 0.05). (2) The time removing the mackintosh at forepassed center was the longest in the model group, followed by the acupuncture group, and shortest in the control group (P < 0.05). (3) Acupuncture method significantly improved the cognitive ability of immature rats, and reduced the latency of searching for platform and swimming distance compared with the model group (P < 0.05). (4) The serum levels of tumor necrosis factor alpha and interleukin-6 in the acupuncture group were significantly lower than those in the model group (P < 0.05). (5) In conclusion, the acupuncture of “Xingnao Kaiqiao” can improve the symptoms and cognitive ability of the immature rat model of cerebral palsy by up-regulating the serum levels of tumor necrosis factor alpha and interleukin-6.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

Key words: Cerebral Palsy, Acupuncture, Tumor Necrosis Factor-alpha, Interleukin-6, Tissue Engineering

CLC Number:

R318

Lou Yuan-jun, Liu Yang, Shan Hai-jun, Cao Cai-hong, Jie Xiao-su. Effect of acupuncture of “Xingnao Kaiqiao” on the behavior of an immature rat model of cerebral palsy and the underlying mechanism[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(49): 7314-7319.

Figures/Tables 1

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