Biological bone mixed with autologous bone for reducible atlantoaxial dislocation via posterior reduction with bone graft fusion

doi:10.3969/j.issn.2095-4344.2016.43.001

Abstract

Abstract:

BACKGROUND: Studies have shown that biological bone and autogenous iliac bone exhibit equivalent lumbar fusion effects, but the former one significantly reduces the risk of secondary surgery and contributes to improving vertebral dysfunction.
OBJECTIVE: To evaluate the effect of biological bone mixed with autologous bone in posterior screw rod internal fixation with bone graft fusion for reducible atlantoaxial dislocation.
METHODS: Seventy-two patients with recoverable atlantoaxial dislocation, including 37 males and 35 females, aged 28-72 years old, were all subjected to posterior atlantoaxial screw rod fixation with bone graft fusion: the atlas was fixed with lateral mass screw or pedicle screw, and the axis fixed with the pedicle screw, lamina screws or lateral mass screw. These patients were assigned into experimental group (n=34) undergoing biological bone mixed with autologous iliac particle bone graft fusion, or control group (n=38) undergoing autologous iliac bone graft fusion. Twelve months later, fusion rate, pain relief, cervical function recovery, cervical activity and complications were compared between the two groups.
RESULTS AND CONCLUSION: After postoperatively 12 months, all patients were satisfied with atlantoaxial dislocation reduction, with a good bone fusion rate up to 100%, and their neck incision healed well by primary intention. The pain, cervical function, cervical curvature and activity were improved significantly in the two groups after treatment (P < 0.05), but there was no significant difference between the two groups. Compared with the control group, the amount of bone mass taken from the patient and pain relief time were lower in the experimental group (P < 0.05). Taken together, the biological bone mixed with autogenous iliac bone for reducible atlantoaxial dislocation via posterior screw rod internal fixation and bone graft fusion can rapidly relieve pain, reduce the amount of bone mass taken from patients, and achieve good fusion effect and cervical functional recovery.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Atlanto-Axial Joint, Internal Fixators, Spinal Fusion, Tissue Engineering

CLC Number:

R318

Luo Xu, Li Dan, Liang Ying-jie.

Biological bone mixed with autologous bone for reducible atlantoaxial dislocation via posterior reduction with bone graft fusion

[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(43): 6389-6395.

Figures/Tables 5

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