Artificial ossicular chain reconstruction: biocompatibility, properties and laryngecartilage defect repair

doi:10.3969/j.issn.2095-4344.2016.25.010

Abstract

Abstract:

BACKGROUND: DefectedLaryngeal cartilage has many alternatives, including autologous cartilage, allograft cartilage and metal stents. Although these materials can achieve desired outcomes in laryngeal cartilage defect repair, certain limitations exist.

OBJECTIVE: To investigate the biocompatibility and properties of artificial ossicular chain reconstruction materials, and to explore the effect of artificial ossicular chain reconstruction materials on laryngeal cartilage defect repair.

METHODS: Porous hydroxyapatite otosteon was prepared by high-temperature calcination of hydroxyapatite, followed by cultured in bone morphogenetic protein solution extracted from fresh human bone to construct bone morphogenetic protein-hydroxyapatite artificial ossicular chain reconstruction material. And then, the biocompatibility and characteristics of the material were analyzed. Forty adult male New Zealand white rabbits were randomly divided into porous hydroxyapatite group and artificial ossicular chain reconstruction material group (n=20 per group), and underwent repair with porous hydroxyapatite material and bone morphogenetic protein-hydroxyapatite artificial ossicular chain reconstruction material respectively after modeling of laryngeal cartilage defect.

RESULTS AND CONCLUSION: There was a significant difference in compressive strength of artificial ossicular chain reconstruction materials with different porosities. No symmetry sphere formed in hollows of the outer surface of the material, with polygonal appearance and with a pore size of 100-200 μm. There were no obvious adverse reactions in both two groups after implantation, but in the artificial ossicular chain reconstruction material group, numerous fibrous connective tissues and obvious bone nodules appeared, and the degradation rate of the material was faster. These results suggest that the bone morphogenetic protein-hydroxyapatite artificial ossicular chain reconstruction material exhibits good biocompatibility and properties, which will obtain satisfactory outcomes for laryngeal cartilage defect repair. So, the material holds a great value of clinical application.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Cartilage, Histocompatibility, Tissue Engineering

CLC Number:

R318

Guo Bei, Yuan Kun, Chen Wei. Artificial ossicular chain reconstruction: biocompatibility, properties and laryngecartilage defect repair[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(25): 3713-3719.

Figures/Tables 6

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