Angiogenic factors in osteonecrosis of the femoral head

doi:10.3969/j.issn.2095-4344.2016.15.010

Abstract

Abstract:

BACKGROUND: A variety of angiogenic factors are involved in bone healing after osteonecrosis of the femoral head.

OBJECTIVE: To explore the role and mechanism of angiogenic factors in osteonecrosis of the femoral head.

METHODS: A computed-based online search of PubMed, Google and SpringerLink databases was performed using the key words of “angiogenic factors, osteonecrosis of the femoral head, vascular endothelial growth factor, angiopoietin-1, fibroblast growth factor-2, hypoxia inducible factor-1, calcitonin gene related peptide and hypoxia inducible factor-1α” for literatures published from December 1980 to May 2015.

RESULTS AND CONCLUSION: Finally, 68 articles were included. Bone angiogenesis which is dependent on special signaling factors in the microenvironment is closely linked with bone repair. A variety of cytokines, such as vascular endothelial growth factor, angiopoietin-1, fibroblast growth factor-2, platelet-derived growth factor, calcitonin gene-related peptide, and hypoxia inducible factor-1α, have been identified to control angiogenesis in different ways and be involved in the repair of necrotic femoral head.
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Cytokines, Neovascularization, Physiologic, Osteogenesis, Tissue Engineering

Hong Guo-ju, He Wei, Wei Qiu-shi, Chen Lei-lei. Angiogenic factors in osteonecrosis of the femoral head[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(15): 2197-2205.

Figures/Tables 1

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