Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (15): 2190-2196.doi: 10.3969/j.issn.2095-4344.2016.15.009

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Reconstruction of the anterior cruciate ligament by allogeneic tendon graft: clinical curative effect and immune rejection

Tu Ze-song, Liang Li-xue, Xing Ji-si     

  1. Department of Orthopedics, Foshan Hospital of TCM, Foshan 528000, Guangdong Province, China
  • Received:2016-02-18 Online:2016-04-08 Published:2016-04-08
  • About author:Tu Ze-song, Master, Associate chief physician, Department of Orthopedics, Foshan Hospital of TCM, Foshan 528000, Guangdong Province, China
  • Supported by:

    the Medical Research Foundation of Foshan Municipal Health Bureau, No. 2011135

Abstract:

BACKGROUND: Problems can occur at the donor site where the autologous tendon graft is taken. Allogenic tissue has become an important graft option for the reconstruction of the anterior cruciate ligament.

OBJECTIVE: To study the clinical curative effect and immune rejection of arthroscopic reconstruction of the anterior cruciate ligament by allogeneic tendon graft.
METHODS: The 120 included patients with anterior cruciate ligament injury were randomized into autologous tendon graft and allogeneic tendon graft groups, respectively, with 60 patients in each group. The autologous semitendinosus-gracilis graft at the affected side or the allogeneic anterior cruciate ligament was implanted into the knee joint in autologous tendon graft group or allogeneic tendon graft group, respectively. Lachman test results, Lysholm and Larson scores of joint function, and postoperative immune rejection were observed and assessed during 2-year follow-up.
RESULTS AND CONCLUSION: Lysholm and Larson scores in autologous tendon graft and allogeneic tendon graft groups were significantly increased after the reconstruction compared with before the reconstruction; however, there was no difference in the scores between both two groups at 2 years after the reconstruction (P > 0.05). At the end of the follow-up, the normal function of the knee joint was restored, and no lag and flexion constraint of the knee joint were observed. No significant differences were observed in Lachman test results between both groups (P > 0.05). Compared with the autologous tendon graft group, immune rejection rates were higher in the allogeneic tendon graft group; however, no significant differences were observed between both groups (P > 0.05). In summary, the allogeneic tendon graft may be a candidate for the reconstruction of the anterior cruciate ligament due to its similar clinical curative effect to the autologous tendon graft and low immune rejection rates.
中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程

Key words: Tendons, Transplantation, Knee Joint, Anterior Cruciate Ligament, Graft Rejection, Tissue Engineering