Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (43): 6983-6987.doi: 10.3969/j.issn.2095-4344.2015.43.018

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Application of nanohydroxyapatite/collagen basal bone materials in lumbar posterolateral bone graft fusion: evaluation of pain scores and bone graft fusion effects

Li Dai1, Yang Ming-min2, Sun Yang3   

  1. 1Anesthesia Pain Center, Changhai Hospital, Second Military Medical University of Chinese PLA, Shanghai 200433, China; 2Orthopedic Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 3the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China
  • Received:2015-07-23 Online:2015-10-15 Published:2015-10-15
  • Contact: Sun Yang, Attending physician, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China
  • About author:Li Dai, M.D., Physician, Anesthesia Pain Center, Changhai Hospital, Second Military Medical University of Chinese PLA, Shanghai 200433, China Yang Ming-min, Master, Physician, Orthopedic Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China Li Dai and Yang Ming-min contributed equally to this work.

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Abstract:

BACKGROUND: Nanohydroxyapatite/collagen basal bone materials have a porous structure which is very close to natural bone. After implanting to the human body, it can be gradually degraded and absorbed over time to play a strongly guiding and bridging role.

OBJECTIVE: To investigate the clinical effect of nanohydroxyapatite/collagen basal bone materials on lumbar posterolateral bone graft fusion.
METHODS: Fifty-eight patients with lumbar disease, including 28 males and 30 females, aged 47 to 81 years were included and were performed lumbar laminectomy via posterior midline approach, or simultaneously performed discectomy and lumbar posterolateral bone graft fusion between transverse process. The bone graft material was nanohydroxyapatite/collagen basal bone repair material. Pedicle screw system was used to make the internal fixation. Patients were followed up for 18 months after treatment. Pain relief and bone graft fusion condition were observed.
RESULTS AND CONCLUSION: Fifty-eight patients had successfully completed the treatment. The incisions healed by first intention. The clinical symptoms and signs were significantly improved compared with before treatment. The complications such as infection, screws shifting and loosening, spondylolisthesis and displacement of adjacent vertebral in fixed segments, and the adverse reactions associated with bone graft material were not occurred during the follow-up. At the 1st, 6th, 12th and 18th months after implanting nanohydroxyapatite/collagen basal bone materials, the visual analog scale scores of the lower limbs and waist were all lower than those before implantation (P < 0.05). At the 12th and 18th months of follow-up, the bone graft rates were 84% and 90%, respectively. These results demonstrate that the application of nanohydroxyapatite/collagen basal bone materials in the process of lumbar posterolateral bone graft fusion can ease the symptoms of lower limb pain and lower back pain, which is conducive to bone graft fusion. 
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Lumbar Vertebrae, Spinal Fusion, Pain Measurement, Tissue Engineering