Rabbit models of optic nerve injury established by the clamping method: an analysis of stress relaxation of injured optical nerve after treatment with Chinese medicine Fuming granules

doi:10.3969/j.issn.2095-4344.2015.40.026

Abstract

Abstract:

BACKGROUND: Many studies have shown that Chinese medicine Fuming granules have certain curative effects on optic nerve injury, but a large number of experimental studies are still needed to verify.

OBJECTIVE: To verify the effect of Chinese medicine Fuming granules on optic nerve injury by the method of stress relaxation experiments.

METHODS: The animal models of optic nerve injury were established by the clamping method. Rats were intervened with Fuming granules by intragastric administration. Model group and normal control group were set for comparison. After 30 days of successive administration, optic nerve injury received stress relaxation experiments in each group, and histomorphology was observed.

RESULTS AND CONCLUSION: In the normal control group, the optic nerve nuclei distributed uniformly without edema, augmentation or inflammatory cells, and the axon and other contents had a clear structure. In the model group, the optic nerve fiber arranged sparsely, presented unclear structure, and axon, karyorrhexis and the other contents changed. In the Fuming granule group, the transect of optic nerve which arranged densely had large area, and most of the axon had a normal structure. The decreases in stress at 7 200 s and stress relaxation were as follows: normal control group > fuming granule group > model group (P < 0.05). Results confirmed that Chinese medicine Fuming granule accelerates the recovery of axoplasm of injured optic nerve, restores the morphology of axons, and contributes to the recovery of injured optic nerve.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

Key words: Tissue Engineering, Biomechanics, Optic Nerve, Stress

CLC Number:

R318

Yuan Yi, Chang Xiao-yu, Li Xin-ying. Rabbit models of optic nerve injury established by the clamping method: an analysis of stress relaxation of injured optical nerve after treatment with Chinese medicine Fuming granules[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(40): 6536-6541.

Figures/Tables 3

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