Hemodynamics simulation of internal carotid artery siphon and relevant influential factors

doi:10.3969/j.issn.2095-4344.2015.37.018

Abstract

Abstract:

BACKGROUND: The siphon of internal carotid artery is a complex of bending and surrounding structure, which has become a research hot in the field of medical imaging and regional anatomy. There is little research on the hemodynamics of internal carotid artery. Finite element analysis provides the basis for the related dynamics research.

OBJECTIVE: To explicit the hemodynamic characteristics of the normal and stenosis internal carotid artery, and to explore the relevant influential factors.

METHODS: Finite element model of the siphon of internal carotid artery was built based on 64-slice spiral CT data, and then, three-dimensional models were constructed using Mimics 10.01 software. There were simulations of the normal and post-stenosis blood flows with ANSYS 13.0 CFX software, to observe the changes of hemodynamics, and to analyze their characteristics and differences.

RESULTS AND CONCLUSION: The normal blood flow at the siphon of internal carotid artery was in a laminar state, but rotation and turbulent flow formed at the two angle regions. The velocity of external bending zone was slower than that of the internal. The slower was the velocity, the more obvious was the turbulence. The wall shear force decreased at the angle regions, and the wall shear force of external bending zone was smaller than that of the internal. At the region of arterial stenosis, the blood flow was sped, and at the downstream, turbulent flow and low zone of wall shear force were formed. With the increase of stenosis severity, the turbulent flow and low wall shear force area were expanded. Central stenosis showed more obvious effects than the eccentric one. The degree of stenosis and bending at the siphon of internal carotid artery can directly influence the formation of turbulent flow and low wall shear force area, which are more obvious at the external bending zone and central stenosis.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Tissue Engineering, Biomechanics, Carotid Artery, Internal, Finite Element Analysis

CLC Number:

R318

Huang Li-dan, Deng Li-zhu, Zhao Wen-jun, Chen Li-jun, Duan Shao-yin. Hemodynamics simulation of internal carotid artery siphon and relevant influential factors[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(37): 5998-6004.

Figures/Tables 4

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