Poly(butylene succinate)/polypropylenecarbonate biofilms: preparation and performanc

doi:10.3969/j.issn.2095-4344.2015.21.014

Abstract

Abstract:

BACKGROUND: Poly(butylene succinate) (PBS) and polypropylenecarbonate (PPC) are new medical materials developed in recent years, characterized as good biocompatibility, biodegradability and the low price.
OBJECTIVE: To prepare the PBS/PPC biofilm by electrostatic spinning method and evaluate its physical and chemical properties, degradation performance and effect on cell proliferation in vitro.
METHODS: The PBS/PPC biofilm was prepared using electrostatic spinning method: 0.9 g PBS and 0.9 g PPC were dissolved in 10 mL of trichloromethane at room temperature and stirred magnetically until they were fully
dissolved. Then, the spinning solution was added into a spinning tube with a distance of about 15 cm and at a voltage of 18 kV. The surface morphology was observed by scanning electron microscopy. The intensity, contact angle and water absorption, pH value and weight loss in the process of in vitro degradation were measured. MG63 cells were co-cultured with the biofilm for 7 days and cell proliferation was detected by cell counting kit-8.
RESULTS AND CONCLUSION: The PBS/PPC biofilm showed a porous structure with interconnected pores. The fiber diameter was about 0.88 μm, the average aperture was about 5.68 μm, the porosity was 78.3%, the fracture intensity was 2.31 MPa, the elongation rate at break was 23.48%, the average value of contact angle was 87°, and the water absorption rate was 68.54%. During the biofilm degradation, the pH value decreased gradually andreduced to 6.76 at 12 weeks; meanwhile, the biofilm degraded equally and gradually, and the weight loss rate was 6.04% at the end of the 12th week. The results of cell counting kit-8 showed that the PBS/PPC biofilm could promote cell proliferation. Overall, the PBS/PPC biofilm has good physical and chemical properties, good space-making feature, wettability and degradability, which can provide sufficient time for bone tissue regeneration.

Key words: Biocompatible Materials, Biofilms, Bone Regeneration

CLC Number:

R318

Ma Yao, Chu Shun-li, Sun Yue, Ma Shan-shan, Li Xue, Zhang Tian-shou, Zhou Yan-min. Poly(butylene succinate)/polypropylenecarbonate biofilms: preparation and performanc[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(21): 3355-3360.

Figures/Tables 5

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