Effect and mechanism of hydrogen sulfide in regulating cellular functions

doi:10.3969/j.issn.2095-4344.2014.20.029

Abstract

Abstract:

BACKGROUND: There are an increasing number of studies addressing hydrogen sulfide as the third gaseous signal molecule, to regulate cellular function, but some contradictions emerge.
OBJECTIVE: To summarize the mechanism of hydrogen sulfide regulating cell function based on the current researches.
METHODS: A computer-based online search of the PubMed database (from 1990 to 2013) was performed, with the key words of “hydrogen sulfide, gasotransmitter” in English. Finally 54 related articles were included in the result analysis.
RESULTS AND CONCLUSION: Accumulating evidence has highlighted the contribution of hydrogen sulfide on regulating cell function, and the underlying mechanism is very complex. Traditional signal molecule (such as estrogen and neuromediators) may amplify the signals for signal transduction through a series of cascade reaction, but the gaseous signal molecule promotes cell metabolism through the post-transcriptional modification of intracellular target protein. The majority of studies indicate that hydrogen sulfide plays an antioxidant, anti-inflammatory and anti-apoptotic role in the physiological concentration, but there are some contradictions in terms of inflammation and apoptosis research. Therefore, further study on the mechanism of hydrogen sulfide should be implemented.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: hydrogen sulfide, cystathionine-β-synthase, cystathionine-γ-lyase, inflammation, apoptosis

CLC Number:

R318

Wang Shi-jun, Li Yu-ting, Sun Hao-lin, Li Chun-de, Wang Tian-long. Effect and mechanism of hydrogen sulfide in regulating cellular functions[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(20): 3275-3280.

Figures/Tables 1

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