Peripheral blood mononuclear cell transplantation for liver cirrhosis

doi:10.3969/j.issn.2095-4344.2013.36.011

Abstract

Abstract:

BACKGROUND: Compared with bone marrow transplantation, peripheral blood stem cell transplantation has its own advantages, including rich resources of stem cells from the peripheral blood, convenient and easy collection, without anesthesia, small trauma, easily accepted, high safety, and easy to restore the patient’s hematopoietic system.
OBJECTIVE: To observe the function and safety of autologous peripheral blood mononuclear cells in the treatment of patients with decompensated cirrhosis.
METHODS: Four patients with decompensated liver cirrhosis were selected from November 2010 to July 2011 in the First Affiliated Hospital of Dalian Medical University, aged 31-67 (averagely 44 years). Among them, three cases had hepatitis B, and another one had autoimmune liver disease. Peripheral blood stem cells were collected after being mobilized by granulocyte colony stimulating factor. Then, autologous peripheral blood stem cells were transplanted via a hepatic artery catheter.
RESULTS AND CONCLUSION: There were no adverse reactions such as fever, bleeding and nausea after peripheral blood stem cell collection and hepatic artery transplantation. Symptoms such as fatigue, poor appetite and abdominal distension gradually improved at 1, 3 and 6 months after transplantation. Liver function and liver fibrosis indexes were improved to some extent after transplantation.

Key words: stem cells, peripheral blood stem cell transplantation, liver cirrhosis, treatment outcome

CLC Number:

R394.2

Zhu Ying, Lang Shuai, Cong Qing-wei, Zhao Gang . Peripheral blood mononuclear cell transplantation for liver cirrhosis[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(36): 6449-6454.

Figures/Tables 3

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