Hepatic arterial transplantation of autologous bone marrow mesenchymal stem cells in treatment of decompensated liver cirrhosis

doi:10.3969/j.issn.2095-4344.2013.36.012

Abstract

Abstract:

BACKGROUND: Autologous bone marrow mesenchymal stem cells can treat decompensated liver cirrhosis, however, little evidence has addressed the controlled clinical research in hepatitis B patients with decompensated live cirrhosis.
OBJECTIVE: To evaluate the clinical efficacy and safety of autologous bone marrow mesenchymal stem cells in the treatment of hepatitis B with decompensated live cirrhosis.
METHODS: A total of 67 hepatitis B patients with decompensated live cirrhosis were divided into two groups according to their wishes to receive stem cell transplantation. The control group (34 patients) only received oral administration of nucleoside analog antivirus and supportive treatment. The treatment group (33 patients) received autologous bone marrow mesenchymal stem cells transplantation via hepatic artery plus antivirus and supportive treatment. The liver functional index, clinical signs and symptoms, adverse reactions were observed and compared at 4, 12, 24 weeks after treatment.
RESULTS AND CONCLUSION: After treatment, all patients’ symptoms were improved to varying degrees. After 4 weeks of treatment, the liver functional indexes were all significantly improved compared with before treatment, the levels of alanme aminotransferase, cholinesterase and prothrombin activity in treatment group were significantly ameliorated compared with control group (P < 0.05). At 12 and 24 weeks of treatment, the alanme aminotransferase, albumin, total bilirubin, cholinesterase and prothrombin activity in control group and treatment group showed statistically significant differences compared with before treatment (P < 0.05). At the same time point, all the indicators in the treatment group were significantly ameliorated compared with control group (P < 0.05). The Child-pugh score and model for end-stage liver disease score declined at 4, 12, 24 weeks after treatment, showing significant differences compared with before treatment. The difference was also significant at the same time point between two groups. The treatment of nucleoside analogue antivirus combined with autologous bone marrow mesenchymal stem cells transplantation on hepatitis B patients with decompensated liver cirrhosis is an effective method to improve liver function and blood coagulation function, with symptom improvement, safety and low risk.

Key words: stem cells, transplantation, autologous, liver cirrhosis, hepatitis B

CLC Number:

R394.2

Ouyang Shi, Liu Shu-ren, Cheng Tao, Chen Yang-shu, Kong Xiang-ping, Zhou Chi-long, Mu Liang-jing. Hepatic arterial transplantation of autologous bone marrow mesenchymal stem cells in treatment of decompensated liver cirrhosis[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(36): 6455-6461.

Figures/Tables 5

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