Development and application of special-purpose grafter by femoral head decompression combined with bone marrow mesenchymal stem cells transplantation based on three-dimensional printing technology

doi:10.3969/j.issn.2095-4344.2016.44.014

Abstract

Abstract:

BACKGROUND: Autologous tissue-engineered bone marrow mesenchymal stem cells (BMSCs) transplantation is one of the most common methods of treating early osteonecrosis of femoral head, but now there is still no any special-purpose grafter available in the market. Such surgical transplantation is a laborious, time-consuming and tedious process, which goes against its clinical promotion.

OBJECTIVE: To develop a supporting, efficient, special-purpose grafter, to solve the difficulty in stem cells transplantation during core decompression of femoral head.

METHODS: CAD software was used to perform solid modeling for this special-purpose grafter and print them by three-dimensional (3D) fast printing technology. The performance of this special-purpose grafter was tested by femoral head core decompression combined with BMSCs transplantation. It was compared with traditional surgical instrument in terms of duration of operation, intraoperative blood loss, visual analogue scale (VAS) of stem cell/biological fiber collagen complex omission amount and doctor’s satisfaction score.

RESULTS AND CONCLUSION: (1) A kind of special-purpose grafter was developed by 3D printing technology rapidly. (2) Compared with the control group, duration of operation, intraoperative blood loss, VAS scores and doctor’s satisfaction scores were significantly improved in the trial group (P < 0.05). (3) CAD software combined with 3D printing technology is a highly efficient means for front-line clinicians to perform independent development. The research and development of this special-purpose grafter provides a perfect solution to the laborious, time-consuming and tedious process of cell/biological collagen fiber transplantation.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Femur Head Necrosis, Computer-Aided Design, Mesenchymal Stem Cells, Cell Transplantation, Tissue Engineering

CLC Number:

R318

Wang Jian-ji, Yang Long, Li Jing, Sun Qi, Zuo Wei-min, Ren Qi-feng, Sun Yu, Wu Zhan-yu, Zou Qiang, Ma Min-xian, Ye Chuan. Development and application of special-purpose grafter by femoral head decompression combined with bone marrow mesenchymal stem cells transplantation based on three-dimensional printing technology[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(44): 6636-6642.

Figures/Tables 4

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