Recombinant bovine basic fibroblast growth factor gel prevents dry socket syndrome after toothextraction

doi:10.3969/j.issn.2095-4344.2013.34.006

Abstract

Abstract:

BACKGROUND: Recombinant bovine basic fibroblast growth factor is a manifold effect cytokine which can promote angiogenesis, wound healing, tissue repair and bone regeneration. Recombinant bovine basic fibroblast growth factor with good histocompatibility is easy to operate and has been widely used in oral and maxillary surgery.

OBJECTIVE: To evaluate the effect of recombinant bovine basic fibroblast growth factor against dry socket syndrome after tooth extraction.

METHODS: A total of 160 patients who had been extracted mandibular third molar were selected and randomly divided into two groups. In the experimental group, recombinant bovine basic fibroblast growth factor was put into the sockets after mandibular third molars were extracted, while in the control group, we let the wounds to be healed naturally without any materials. The incidence of dry socket syndrome was observed and compared between two groups at 3 days, 5 days and 1 week after tooth extraction.

RESULTS AND CONCLUSION: One patient had dry socket after operation in the experimental group, and the incidence was 1.25%. In the control group, 10 patients suffered from dry socket, and the incidence was 12.5%. There was a significant difference in the incidence of dry socket between the two groups (P < 0.01). There was visible granulation tissue within the tooth socket after tooth extraction in the experimental group, and extraction sockets narrowed and were filled with granulation tissues, which was 1-2 days earlier than the control group. No allergies, tissue hyperplasia and other local and systemic reactions occurred in patients receiving implantation of recombinant bovine basic fibroblast growth factor gel. These findings indicate that local implantation of recombinant bovine basic fibroblast growth factor gel after mandibular tooth extractions can speed up the healing of dental extraction wounds.

Key words: biomaterials, tissue-engineered oral materials, basic fibroblast growth factor, dry socket, impacted teeth, gel, bioactive factors, tooth extraction, allergies, tissue hyperplasia, complications

CLC Number:

R318

Xue Ling-fa, Xu Yao-xiang, Yue Jin, Wang Shuang-yi, Xiao Wen-lin, Zhang Chun-yang. Recombinant bovine basic fibroblast growth factor gel prevents dry socket syndrome after toothextraction[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(34): 6097-6102.

Figures/Tables 3

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