Tissue-engineered nerve conduits repair peripheral nerve damage

doi:10.3969/j.issn.2095-4344.2013.12.017

Abstract

Abstract:

BACKGROUND: Theoretically, nerve conduit technology uses the biological or non-biological materials to prefabricate suitable tubular stent to bridge the nerve ends on both sides. And it can promote the nerve regeneration through neural induction and nutrition under the nerve regeneration microenvironment.
OBJECTIVE: To observe the clinical effects of tissue-engineered nerve conduits for repairing peripheral nerve damage.
METHODS: Twenty-four patients with old upper extremity nerve damage were selected, and divided into two groups for the treatment according to voluntary principle. The patients in the experimental group were repaired with tissue-engineered nerve conduits, and those in the control group were repaired with autologous surrounding surface sensory nerve transplantation. All the patients were followed-up for 6 months after treatment to observe the repairing functional effect of limb nerve damage.
RESULTS AND CONCLUSION: After followed-up for 6 months, the limb distal sensory motor function and visual analogue scale scores of the limbs in the two groups were improved compared with those before treatment (P < 0.05), and the experimental group showed better effects (P < 0.05); the sensory and motor nerve conduction velocity of the damaged side in the two groups were improved compared with those before treatment (P < 0.05), and there was no significant difference between the two groups. It indicates that tissue-engineered nerve conduit materials can meet the requirements of nerve repair conduit stent and the clinical application is effective.

Key words: biomaterials, material biocompatibility, nerve conduit, nerve damage, nerve repair, motor nerve conduction, clinical efficacy

CLC Number:

R318

Xu Hai-dong, Zhao Jian-ning, Lu Jun-hao, Chen Yong. Tissue-engineered nerve conduits repair peripheral nerve damage[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(12): 2205-2209.

Figures/Tables 6

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