Hydrophilic and mechanical properties of 3D printed polylactic levodopa as alternative material for bone regeneration

doi:10.3969/j.issn.2095-4344.0981

Abstract

Abstract:

BACKGROUND: There are some disadvantages in traditional polylactic organic polymer materials such as poor cell compatibility and insufficient mechanical strength.

OBJECTIVE: To evaluate the mechanical properties and biocompatibility of 3D printed polylactic levodopa composites.

METHODS: Polylactic scaffold materials were prepared by 3D printing technology (blank group); surface modifications (experimental group) and solute-free modifications (control group) were performed on the surface of polylactic scaffolds by solvent condensation and freeze drying volatilization method. In present study, the hydrophilic angle, compression strength, bending strength, and wear resistance of the above three groups were examined.

RESULTS AND CONCLUSION: (1) The hydrophilic angles of the blank group, the experimental group and the control group were (89±5)°, (36±2)°, and (87±4)°, respectively, which was significantly less in the experimental group than the other two groups (P < 0.05). (2) The maximum compressive strengths of the blank group, the experimental group, and the control group were 142.3 N, 149.4 N, and 140.6 N, respectively, which was significantly higher in the experimental group than the other two groups (P < 0.05). (3) The maximum bending resistance of the blank group, the experimental group, and the control group were 55.8 N, 95.7 N, and 56.7 N, respectively, which was significantly higher in the experimental group than the other two groups (P < 0.05). (4) Within 3 minutes, the friction coefficient and the wear volume of the experimental group were the smallest among the three groups; after 6 minutes, there was no significant difference in the friction coefficients among the three groups. The above results reveal that polylactic levodopa composites have excellent mechanical properties and biocompatibility.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Levodopa, Contact Lenses, Hydrophilic, Biomechanics, Tissue Engineering

CLC Number:

R318

Zheng Chen, Wang Ming-xiao, Liu Bo, Zhang Li-ju, Zhang Na, Wang Yu-guang, Wang Zhi-qiang. Hydrophilic and mechanical properties of 3D printed polylactic levodopa as alternative material for bone regeneration[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(30): 4800-4805.

Figures/Tables 7

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