Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (27): 4312-4318.doi: 10.12307/2024.571
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Fan Yidong1, Qin Gang2, He Kaiyi2, Gong Yufang3, Li Weicai1, Wu Guangtao1
Received:
2023-10-08
Accepted:
2023-11-25
Online:
2024-09-28
Published:
2024-01-26
Contact:
Qin Gang, MD, Chief physician, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, China
About author:
Fan Yidong, Master candidate, Guangxi University of Chinese Medicine, Nanning 530222, Guangxi Zhuang Autonomous Region, China
Supported by:
CLC Number:
Fan Yidong, Qin Gang, He Kaiyi, Gong Yufang, Li Weicai, Wu Guangtao. Expression of immune-related genes in rheumatoid arthritis and a two-sample Mendelian randomization study of immune cells[J]. Chinese Journal of Tissue Engineering Research, 2024, 28(27): 4312-4318.
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2.5 类风湿性关节炎中的免疫学特征改变 根据免疫细胞浸润及其与免疫特征基因的相关性评估类风湿性关节炎的免疫学特征。与健康对照样本相比,28种免疫细胞中单核细胞、自然杀伤细胞、活化B细胞等19种免疫细胞在类风湿性关节炎样本里表现出更高的浸润水平,见图5A。免疫细胞之间的相关性显示他们大多为正相关关系,其中单核细胞与巨噬细胞、肥大细胞等免疫细胞之间有较强相关性,而中性粒细胞、自然杀伤细胞与其他免疫细胞的相关性较弱。记忆B细胞、不成熟B细胞及活化CD8T细胞等免疫细胞与特征基因呈正相关性,未发现负调控关系,见图5B。在免疫检查点中,BTLA、CD48和TIGIT等免疫检查点与特征基因显示出较强正相关关系,见图5C。"
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