Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (35): 5735-5740.doi: 10.12307/2021.308

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Relationship between biological activities of Apelin and Elabela and diseases

Wen Miaomiao1, Fan Junbai2   

  1. 1Shanxi Medical University, Taiyuan 030000, Shanxi Province, China; 2The Second Hospital of Shanxi Medical University, Taiyuan 030000, Shanxi Province, China
  • Received:2020-10-21 Revised:2020-10-24 Accepted:2020-11-21 Online:2021-12-18 Published:2021-08-06
  • Contact: Fan Junbai, Chief physician, the Second Hospital of Shanxi Medical University, Taiyuan 030000, Shanxi Province, China
  • About author:Wen Miaomiao, Master candidate, Shanxi Medical University, Taiyuan 030000, Shanxi Province, China
  • Supported by:
    Shanxi Provincial Applied Basic Research Project, No. 201701D121139 (to FJB)

Abstract: BACKGROUND: Apelin is an endogenous ligand of putative receptor protein related to angiotensin II type 1 receptor (APJ), with multiple subtypes, each of which has different biological activities. In recent years, it has been discovered that Elabela is another ligand of APJ, which plays a key role in the development of the heart and differentiation of the endoderm. Elabela is different from Apelin in time point and area.
OBJECTIVE: To focus on the therapeutic effects and mechanisms for specific diseases based on a large amount of literatures regarding the structure and function of Apelin and Elabela.  
METHODS: Relevant literature searches were conducted in PubMed, CNKI, WanFang Full-text Database, and VIP database. The time limit was from 1993 to 2020. The search terms were “Apelin, Elabela, nervous system, lung disease, high blood pressure, insulin resistance” in English and Chinese, respectively. Abstracts and conclusions were initially screened, and irrelevant literatures were excluded. Finally, 76 literatures were included for results analysis.
RESULTS AND CONCLUSION: Apelin has the effects of relieving pain, reducing lung damage, regulating blood pressure, inhibiting gastric acid secretion, diuresis, reducing insulin resistance, increasing immunity, anti-aging, etc. Elabela is involved in angiogenesis, embryonic development, endoderm differentiation, etc. Both of them are expected to become a therapeutic target for circulatory system, nervous system, and heart diseases, and provide new ideas for the initial prevention of diseases in clinic.

Key words: Apelin, Elabela, angiotensin II, liver cirrhosis, insulin resistance, review

CLC Number: