Application of MXene in biosensors, antibacterial drug loading and biological imaging

doi:10.12307/2021.068

Abstract

Abstract: BACKGROUND: The emerging two-dimensional materials have become a research hotspot in many research fields, among which MXene two-dimensional materials have been widely used in energy, catalysis, biology and other related fields due to their excellent physicochemical properties.
OBJECTIVE: To summarize the current development and future prospects of MXene in the biological field.
METHODS: A computer-based online search of Web of Science, CNKI, and Wanfang databases was performed to retrieve studies regarding MXene in the biological field published between March 2011 and May 2020 with the search terms of “Biomedical MXene, MXene Biosensor, MXene Synergistic Therapy” in English and Chinese.
RESULTS AND CONCLUSION: Low cytotoxicity, high surface area, and strong and wide Near Infrared (NIR) absorption make the MXene family one of the most promising materials for biomedical applications. MXene structure contains abundant oxygen-containing groups which have a high degree of functionalization capability, enabling MXene nanosheets good performance in biomedical field. Therefore, MXenes are currently expanding their usage territory from mechanical, optical, and electronic fields toward biomedical areas. MXenes possess a unique potential for diagnostic imaging, antimicrobial agents, biosensor, and drug delivery. Although the present studies have shown desirable short-term biocompatibility of the MXenes, systematic assessment of long-term in vivo biosafety is essential for the expansion of their biomedical applications. By future investigations, it is expected to observe a rapid growing in the synthesis of new families of MXenes and their bright perspective in biomedical sciences.

Key words: material, two-dimensional material, MXene, nanosheets, biomedicine, biosensor, synergistic therapy, review

CLC Number:

Gao Wei, Xing Wenge, Guo Yaping, Zhang Yongguang, Li Mingjun, Yang Lei, Liang Chunyong. Application of MXene in biosensors, antibacterial drug loading and biological imaging[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(28): 4523-4530.

Figures/Tables 3

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