中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (18): 3333-3336.doi: 10.3969/j.issn.1673-8225.2012.18.023

• 移植与免疫 transplantation and Immunology • 上一篇    下一篇

正常妊娠反复自然流产绒毛及蜕膜组织中细胞因子信号转导负调控因子的表达：改变Th1/Th2平衡调节可影响妊娠结局★

吕兴钰，艾海权，蔡  霞，李晓兰   

  1. 新疆医科大学第一附属医院生殖中心，新疆维吾尔自治区乌鲁木齐市  830054  
  • 收稿日期:2011-10-15 修回日期:2011-12-29 出版日期:2012-04-29 发布日期:2012-04-29
  • 通讯作者: 蔡霞，博士，主任医师，教授，博士生导师，新疆医科大学第一附属医院生殖中心，新疆维吾尔自治区乌鲁木齐市 830054
  • 作者简介:吕兴钰★，女，1978年生，山东省菏泽市人，汉族，新疆医科大学在读硕士，主治医师，主要从事生殖医学研究。Lxyy323@163.com

Expression of suppressor of cytokine signaling in villus and decidua tissue of recurrent spontaneous abortion and normal pregnancy: Changing Th1/Th2 balance can influence the outcome of pregnancy  

Lü Xing-yu, Ai Hai-quan, Cai Xia, Li Xiao-lan   

  1. Reproductive Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi　830054, Xinjiang Uygur Autonomous Region, China
  • Received:2011-10-15 Revised:2011-12-29 Online:2012-04-29 Published:2012-04-29
  • Contact: Cai Xia, Doctor, Chief physician, Professor, Doctoral supervisor, Reproductive Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi　830054, Xinjiang Uygur Autonomous Region, China
  • About author:Lü xing-yu★, Studying for master’s degree, Attending physician, Reproductive Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi　830054, Xinjiang Uygur Autonomous Region, China Lxyy323@163.com

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摘要：

背景：细胞因子信号转导负调控因子(suppressors of cytokine signaling, SOCS)参与多种细胞因子信号通路的调节，SOCS1-3对妊娠的调节作用较为突出。
目的：通过检测反复自然流产患者和正常妊娠绒毛及蜕膜组织中SOCS3蛋白表达，了解反复自然流产患者SOCS3蛋白的表达。
方法：Westen blotting 方法检测反复自然流产患者和正常妊娠绒毛组织及蜕膜组织SOCS3的表达。
结果与结论：与正常妊娠组相比，反复自然流产组SOCS3在绒毛组织中表达减少(P < 0.05)，在蜕膜组织中表达减少(P < 0.01)。推测SOCS3蛋白可能影响妊娠结局，反复自然流产组SOCS3表达降低，可能导致Th2反应降低，从而导致流产发生。
 

关键词: 细胞因子信号转导抑制蛋白, 反复自然流产, 绒毛组织, 蜕膜组织, Th1/Th2

Abstract:

BACKGROUND: Suppressor of cytokine signaling (SOCS) has involved in the regulation of signaling pathways of many cytokines, SOCS1-3 are more prominent in the regulation of pregnancy.
OBJECTIVE: To detect the different expression of SOCS3 protein in villus and decidua tissue of normal early pregnancy and recurrent spontaneous abortion patients.
METHODS: The protein expression of SOCS3 in villus and decidua tissue of normal early pregnancy and recurrent spontaneous abortion patients was detected by Westen blotting.
RESULTS AND CONCLUSION: Compared with normal early pregnancy group, the protein expression of SOCS3 in villus      (P < 0.05) and decidua tissue (P < 0.01) was significantly decreased in recurrent spontaneous abortion group. SOCS3 protein might influence the outcome of the pregnancy. The decreased expression of SOCS3 might lead to the decrease of Th2 reaction and then the abortion. 

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