中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (37): 6895-6900.doi: 10.3969/j.issn.1673-8225.2011.37.014

• 组织构建与生物力学 tissue construction and biomechanics • 上一篇    下一篇

常氧、低氧训练条件下肌肉蛋白表达及肌张力的变化

任平社1，任文君2   

  1. 1陕西科技大学，陕西省西安市  710021
    2西安交通大学，陕西省西安市710049
  • 收稿日期:2011-06-29 修回日期:2011-07-29 出版日期:2011-09-10 发布日期:2011-09-10
  • 作者简介:任平社★，男，1974年生，陕西省兴平市人，汉族，2005年西安体育学院毕业，硕士，主要从事体育教学与训练研究。 renpingshe@ 126.com
  • 基金资助:

    国家自然科学基金资助项目(30501583)；陕西省国际合作重点项目资助项目(2010kw-05)。

Muscle protein expression and muscle tension change under normoxic and hypoxic training conditions

Ren Ping-she1, Ren Wen-jun2   

  1. 1Shaanxi University of Science and Technology, Xi’an  710021, Shaanxi Province, China
    2Xi’an Jiaotong University, Xi’an  710049, Shaanxi Province, China
  • Received:2011-06-29 Revised:2011-07-29 Online:2011-09-10 Published:2011-09-10
  • About author:Ren Ping-she★, Master, Shaanxi University of Science and Technology, Xi’an 710021, Shaanxi Province, China renpingshe@ 126.com
  • Supported by:

    the National Natural Science Foundation of China, No.30501583*; a grant from International Cooperation Major Program of Shaanxi Province, No.2010kw-05*

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被引次数

4

摘要：

背景：环境因素以及运动水平均可显著引起肌纤维结构的变化。
目的：观察常氧、低氧训练条件下大鼠腓肠肌肌球蛋白、肌动蛋白的表达及肌张力的变化特征。
方法：将SD大鼠随机分为常氧对照组(氧体积分数20%，不进行任何处理)、常氧训练2，4，6周组、低氧训练2，4，6周组、低氧对照组(氧体积分数12.7%，不进行训练)。
结果与结论：无论在常氧还是低氧环境下，运动训练后大鼠腓肠肌质量、腓肠肌肌纤维截面积均明显增加(P < 0.05，P < 0.01)；运动训练6周后大鼠腓肠肌等长收缩最大张力显著增加(P < 0.01)；经运动训练后大鼠腓肠肌总MHC及α-actin随着训练时间的延长逐步升高，并且低氧训练组升高幅度高于常氧训练组。说明低氧训练可以更有效促进骨骼肌肌球蛋白、肌动蛋白的表达，增强肌张力，强化Ⅰ型肌纤维，并且训练时间越长，效果越显著，表明低氧训练是一种有效的运动训练途径。

关键词: 低氧训练, 腓肠肌, 生理功能, 最大肌力, 运动 

Abstract:

BACKGROUND: Environment and sports can cause great changes in muscle fibers.
OBJECTIVE: To observe rat gastrocnemius myosin and actin expression and muscle tension changes under normoxic and hypoxic training conditions.
METHODS: SD rats were randomly divided into a normoxic control (20% oxygen, without any treatments), normoxic training 2, 4 and 6 weeks groups, hypoxic training 2, 4, and 6 weeks groups, and a hypoxic control group (12.7% oxygen, without training).
RESULTS AND CONCLUSION: No matter under normoxic or hypoxic environment, rat gastrocnemius mass and gastrocnemius muscle fiber crossection area were significantly increased after exercise training (P < 0.05, P < 0.01). After 6 weeks of exercise training, the maximum tension of gastrocnemius muscle in isometric contraction was significantly increased (P < 0.01). After exercise training, total MHC and α-actin expression in rat gastrocnemius muscle was gradually increased with the prolongation of training time and the increase was greater in the hypoxic training groups than in the normoxic training groups. Results demonstrated that hypoxic training can effectively promote gastrocnemius myosin and actin expression and increase muscle tension, and strengthen type Ⅰmuscle fiber, and that the longer the training time, the better the efficacy, suggesting that hypoxic training is an effective method of exercise training.

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