中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (32): 5987-5990.doi: 10.3969/j.issn.1673-8225.2011.32.022

• 脐带脐血干细胞 umbilical cord blood stem cells • 上一篇    下一篇

脐带间充质干细胞移植治疗终末期肝硬化的疗效及安全性

周炳喜，郭俊贤，韩双印，张延瑞   

  1. 河南省人民医院消化内科，河南省郑州市  450003
  • 收稿日期:2011-06-08 修回日期:2011-07-04 出版日期:2011-08-06 发布日期:2011-08-06
  • 作者简介:周炳喜★，男，1968年生，安徽省枞阳县人，汉族，2006年郑州大学毕业，硕士，副主任医师，主要从事终末期肝病的治疗及消化道肿瘤内镜下治疗。 zhoubingxi@medmail.com.cn

Effect and safety of umbilical cord mesenchymal stem cells transplantation on end-stage liver cirrhosis

Zhou Bing-xi, Guo Jun-xian, Han Shuang-yin, Zhang Yan-rui   

  1. Department of Digestion, Henan Provincial People’s Hospital, Zhengzhou  450003, Henan Province, China
  • Received:2011-06-08 Revised:2011-07-04 Online:2011-08-06 Published:2011-08-06
  • About author:Zhou Bing-xi★, Master, Associate chief physician, Department of Digestion, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China zhoubingxi@medmail.com.cn

PDF

676

被引次数

17

摘要：

背景：骨髓间充质干细胞移植已应用于治疗终末期肝病并取得一定疗效。
目的：观察脐带间充质干细胞治疗终末期肝硬化患者的疗效及安全性。
方法：无菌条件下分离培养脐带间充质干细胞，选择60例肝硬化患者，在内科治疗基础上经肝动脉插管进行脐带间充质干细胞移植。
结果与结论：移植2，4，8，12周后，患者血清白蛋白、前白蛋白水平逐渐升高(P < 0.05)，总胆红素、凝血酶原时间明显低于治疗前水平(P < 0.05)。移植后患者乏力、腹胀、纳差明显好转，未发生与移植相关的严重并发症。说明脐带间充质干细胞治疗终末期肝硬化安全有效，能改善患者的肝功能、凝血功能及临床症状。

关键词: 肝硬化, 脐带间充质干细胞, 终末期, 疗效, 安全性

Abstract:

BACKGROUND: Bone mesenchymal stem cells (BMSCs) transplantation has been used for end-stage liver cirrhosis, and obtained some results.
OBJECTIVE: To observe the effect and safety of umbilical cord mesenchymal stem cells (UCMSCs) transplantation on end-stage hepatic cirrhosis.
METHODS: UCMSCs were isolated under sterile conditions. Sixty cases of liver cirrhosis received basic medication and UCMSCs transplantation by way of hepatic artery.
RESULTS AND CONCLUSION: After UCMSCs treatment, the level of albumin, prealbumin and fibrinogen were significantly increased (P < 0.05), and the levels of total bilirubin and prothrombin time were obviously reduced (P < 0.05). The symptoms such as fatigue, abdominal distension, anorexia relieved after treatment. UCMSCs transplantation for end-stage liver cirrhosis is safe and effective, and it can improve patients’ liver function, blood clotting and relieve clinical symptoms.

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