中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (47): 8826-8830.doi: 10.3969/j.issn.2095-4344.2012.47.019

• 生物材料基础实验 basic experiments of biomaterials • 上一篇    下一篇

纤维素薄膜包衣缓释剂的设计和性能考察

熊华蓉1，谭群友2，滕永真1，王 睿1，张景勍1   

  1. 1重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室，重庆市400016
    2第三军医大学大坪医院野战外科研究所胸外科，重庆市 400042
  • 收稿日期:2012-03-02 修回日期:2012-05-03 出版日期:2012-11-18 发布日期:2012-11-18
  • 通讯作者: 张景勍，教授，重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室，重庆市 400016 zjqrae01@163.com
  • 作者简介:熊华蓉☆，女，1985年生，四川省遂宁市人，在读博士，主要从事药物载体与新技术研究。

Cellulose film-coated sustained-release formulation and its properties

Xiong Hua-rong1, Tan Qun-you2, Teng Yong-zhen1, Wang Rui1, Zhang Jing-qing1   

  1. 1Medicine Engineering Research Center, Chongqing Key Laboratory of Biochemical ＆Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, China
    2Department of Thoracic Surgery, Institute of Surgery Research of Daping Hospital, the Third Military Medical University, Chongqing 400042, China
  • Received:2012-03-02 Revised:2012-05-03 Online:2012-11-18 Published:2012-11-18
  • Contact: Zhang Jing-qing, Professor, Medicine Engineering Research Center, Chongqing Key Laboratory of Biochemical ＆Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, China zjqrae01@163.com
  • About author:Xiong Hua-rong☆, Studying for doctorate, Medicine Engineering Research Center, Chongqing Key Laboratory of Biochemical ＆Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, China

PDF

444

被引次数

2

摘要：

背景：乙基纤维素是常用的不溶性高分子材料，具有良好的成膜性能和机械性能，可用于缓释包衣材料。
目的：制备美斯地浓纤维素薄膜包衣缓释剂，并考察其性能。
方法：以羟丙甲基纤维素为缓释材料，以体外累计释放度为指标，运用单因素考察确定片芯处方，以乙基纤维素为薄膜包衣材料，采用正交实验设计优选出包衣处方，制备美斯地浓纤维素薄膜包衣缓释剂，考察其体外释放性能及对光和热的稳定性能。
结果与结论：通过单因素考察确定以羟丙甲纤维素 K15M作为缓释材料，体积分数95%乙醇溶液为黏合剂制备缓释片片芯，正交实验设计优选出包衣处方为：包衣增重为10%、致孔剂用量为3%、抗黏剂用量为0.1%，纤维素薄膜包衣缓释剂在2，4，8 h的体外累计释放度为(19.52±0.72)%，(42.31±0.61)%，(86.50±0.72)%，具有良好的缓释特征，且对光和热稳定。

关键词: 美斯地浓, 羟丙甲纤维素, 纤维素, 缓释剂, 性能, 生物材料

Abstract:

BACKGROUND: The ethyl cellulose is a commonly used insoluble polymer material that has a good film formation properties and mechanical properties, and can be used as the sustained-release coating material.
OBJECTIVE: To prepare mestinon cellulose film-coated sustained-release formulation and to study its properties.
METHODS: The core of the formulation was optimized by single factor method based on sustained-release material of hydroxypropylmethylcellulose and indicator of in vitro cumulative release. And the film coating was optimized by the orthogonal methodology based on ethyl cellulosesustained-release material. The mestinon cellulose film-coated sustained-release formulation was successfully prepared and the in vitro release behavior and stability to light and heat was investigated.
RESULTS AND CONCLUSION: The hydroxypropylmethylcellulose K15M was determined as sustained-release material and 95% ethanol solution was determined as binder by single factor investigation. Orthogonal design method was used to optimize coating prescription: the coating weight was 10%, the content of porogen was 3% and the amount of the anti-adhesion promoter was 0.1%; the accumulated release rates of mestinon cellulose film-coated sustained-release were (19.52±0.72)%, (42.31±0.61)% and (86.50±0.72)% at 2, 4 and 8 hours, respectively. The mestinon cellulose film-coated sustained-release possessed good sustained-release characteristics and stability in light and hot.

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