中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (36): 9632-9639.doi: 10.12307/2026.369

• 组织工程相关大数据分析 Big data analysis in tissue engineering • 上一篇    下一篇

膝骨关节炎治疗研究热点及趋势的可视化分析

贝朝涌，朱家琳，余政泽，师牛津，李华蕊，彭峰林   

  1. 广西师范大学体育与健康学院，广西壮族自治区桂林市   541006
  • 收稿日期:2025-07-09 修回日期:2025-09-10 出版日期:2026-12-28 发布日期:2026-05-26
  • 通讯作者: 彭峰林，博士，教授，广西师范大学体育与健康学院，广西壮族自治区桂林市 541006
  • 作者简介:贝朝涌，男，1971年生，广西壮族自治区桂林市人，汉族，广西师范大学体育与健康学院在读博士，主任医师，主要从事骨创伤、骨组织工程、骨关节的研究。
  • 基金资助:
    广西研究生教育创新计划项目(YCBZ2025084)，课题名称：DBM支架复合BMSC在其外泌体诱导下成骨效果的实验研究，项目负责人：贝朝涌

Visualization analysis of research hotspots and trends in the treatment of knee osteoarthritis

Bei Chaoyong, Zhu Jialin, Yu Zhengze, Shi Niujin, Li Huarui, Peng Fenglin   

  1. School of Physical Education and Health, Guangxi Normal University, Guilin 541006, Guangxi Zhuang Autonomous Region, China
  • Received:2025-07-09 Revised:2025-09-10 Online:2026-12-28 Published:2026-05-26
  • Contact: Peng Fenglin, PhD, Professor, School of Physical Education and Health, Guangxi Normal University, Guilin 541006, Guangxi Zhuang Autonomous Region, China
  • About author:Bei Chaoyong, PhD candidate, Chief physician, School of Physical Education and Health, Guangxi Normal University, Guilin 541006, Guangxi Zhuang Autonomous Region, China
  • Supported by:
    Innovation Project of Guangxi Graduate Education, No. YCBZ2025084 (to BCY)

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摘要：



文题释义：
文献计量学：指应用数学及统计学方法来分析文献及其影响力的学科，主要通过计算文献的数量、分析文献间的引用关系及关键词频率等追踪作者或机构合作模式以及识别高频词汇等途径帮助学者了解某个研究领域的关注焦点、发展脉络、重要贡献者以及未来的研究趋势。
似然比(likelihood ratio，LR)：是反映真实性的一种指标，属于同时反映灵敏度和特异度的复合指标。

背景：已有膝骨关节炎不同治疗方式的对比研究，但目前尚缺少长时间跨度且纳入文献数量较多的膝骨关节炎治疗全球研究趋势及可视化研究。
目的：通过文献计量学方法，揭示近20年来膝骨关节炎治疗研究的全球发展趋势，对研究主体及研究热点进行可视化分析，为后续研究提供一定的数据参考。
方法：从Web of Science核心合集数据库获取膝骨关节炎相关研究的文献数据，运用CiteSpace文献可视化软件对发文趋势、主要机构、核心作者、关键词、中心性、聚类和共引文献进行分析，以揭示该领域的知识基础及前沿热点。
结果与结论：①最终纳入2005-2024年发表的5 806篇文献，相关文献呈现明显增长趋势；中国、美国和澳大利亚在领域占据主导地位，其中哈佛大学为发文最多的机构。②关键词共现分析发现，临床中一直在尝试将富血小板血浆、关节成形术、玻璃酸钠及针灸等治疗方法应用到膝骨关节炎的治疗中。③关键词突现表明，细胞、单腔膝关节置换术、基质血管分数等是近年来膝骨关节炎治疗领域的新兴热点。④文献共被引分析发现，共被引中心度较高的文献主要是对膝骨关节炎治疗领域的药物、非药物治疗方法及相应指南的探讨，这些文献构成了膝骨关节炎治疗领域的重要知识基础。⑤共引文献聚类分析发现，目前间充质干细胞、富血小板血浆等生物制剂对膝骨关节炎的治疗存在争议，仍需大样本随机对照试验验证其疗效，反映了目前及未来领域内的研究热点。
https://orcid.org/0000-0003-3762-9745 (贝朝涌)


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 膝骨关节炎, 文献计量学, CiteSpace, 可视化分析, 研究热点

Abstract: BACKGROUND: Comparative studies have been conducted on different treatment methods for knee osteoarthritis, but there remains a relative paucity of visualized studies on global research trends in the treatment of knee osteoarthritis that span a long period of time and include a large number of literature sources.
OBJECTIVE: To reveal global research trends over the past two decades in the treatment of knee osteoarthritis through bibliometric methods and to conduct visualized analyses of research entities and hotspots, thereby providing references for future studies.
METHODS: This study selected relevant literature from the Web of Science Core Collection database. CiteSpace software was used for visual analysis of publication trends, main institutions, core authors, keywords, centrality, clustering and co-cited literature, to reveal the knowledge base and frontier hotspots in this field.
RESULTS AND CONCLUSION: (1) A total of 5 806 publications from 2005 to 2024 were finally included; the overall number of publications from the selected articles showed an upward trend. China, the United States, and Australia are the three countries with the largest number of publications in this field. Harvard University is the most prolific research institution. (2) Keywords co-occurrence analysis displayed that platelet-rich plasma, arthroplasty, sodium hyaluronate and acupuncture have been attempted for the treatment of knee osteoarthritis in clinical practice. (3) Burstiness analysis of keywords identified emerging hotspots such as cells, unicompartmental knee arthroplasty, and stromal vascular fraction in recent years. (4) Co-citation analysis revealed that foundational literature focusing on pharmacological or non-pharmacological treatments and clinical guidelines constituted the basis of this field. (5) Cluster analysis revealed that there are controversies regarding the treatment of knee osteoarthritis with biological agents such as mesenchymal stem cells and platelet-rich plasma. Large sample randomized controlled trials are still needed to verify their efficacy, reflecting the current and future research hotspots in field. 


Key words: knee osteoarthritis, bibliometrics, CiteSpace, visualization analysis, research hotspots

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