中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (35): 9327-9335.doi: 10.12307/2026.413

• 组织工程相关大数据分析 Big data analysis in tissue engineering • 上一篇    下一篇

药物相关性颌骨坏死的文献可视化分析

王  权1，唐正龙2   

  1. 1贵州医科大学口腔医学院，贵州省贵阳市   550000；2贵州医科大学附属口腔医院，贵州省贵阳市   550000 
  • 收稿日期:2025-09-25 修回日期:2026-01-04 出版日期:2026-12-18 发布日期:2026-04-30
  • 通讯作者: 唐正龙，教授，博士生导师，主任医师，贵州医科大学附属口腔医院，贵州省贵阳市 550000
  • 作者简介:王权，男，2000年生，江苏省徐州市人，汉族，贵州医科大学口腔医学院在读硕士研究生，主要从事骨髓炎方向研究。
  • 基金资助:
    国家自然科学基金项目(82460193)，项目负责人：唐正龙

Visualization analysis of literature on medication-related osteonecrosis of the jaw

Wang Quan1, Tang Zhenglong2   

  1. 1School of Stomatology, Guizhou Medical University, Guiyang 550000, Guizhou Province, China; 2Stomatological Hospital of Guizhou Medical University, Guiyang 550000, Guizhou Province, China
  • Received:2025-09-25 Revised:2026-01-04 Online:2026-12-18 Published:2026-04-30
  • Contact: Tang Zhenglong, Professor, Doctoral supervisor, Chief physician, Stomatological Hospital of Guizhou Medical University, Guiyang 550000, Guizhou Province, China
  • About author:Wang Quan, MS candidate, School of Stomatology, Guizhou Medical University, Guiyang 550000, Guizhou Province, China
  • Supported by:
    National Natural Science Foundation of China, No. 82460193 (to TZL)

PDF

1

摘要：


文题释义：
药物相关性颌骨坏死：是由抗骨吸收药物或抗血管生成药物引发的颌骨代谢失衡及坏死性疾病，常见于恶性肿瘤骨转移和骨质疏松症患者。
文献计量学：以文献体系及其属性特征为研究对象，采用统计学与数学方法，定量分析文献的分布规律、引用关系、研究热点及发展趋势的学科。
可视化分析：一种将数据内在关联及信息结构以图谱形式呈现的研究方法，能够帮助研究者快速了解相关研究领域的发展脉络、核心主题与动态演进路径。

背景：对药物相关性颌骨坏死领域的主题文献进行计量学与可视化分析，对于深入理解该领域的研究基础与前沿动态具有重要意义。
目的：通过文献计量学、引证分析及可视化分析以揭示药物相关性颌骨坏死领域的研究热点、现状与趋势。 
方法：基于Web of Science核心合集(SCI-Expanded)，检索并筛选2004–2024年间发表且被引频次排名前100的药物相关性颌骨坏死研究文献；首先进行文献计量学分析，提取并统计年发文量、国家、机构、作者、期刊来源及共被引关系等核心特征，随后运用CiteSpace 6.4.R1软件绘制可视化知识图谱，以识别研究热点与发展趋势。  
结果与结论：纳入文献总被引频次达12 337次，篇均年引用频次为6.17次。国际核心合作网络稳定紧密，其中，美国、伦敦大学及Salvatore L. Ruggiero教授分别在高被引论文产出的国家、研究机构和作者中位列首位。热点关键词主要包括风险因素、双膦酸盐、癌症和破骨细胞，突现关键词以“Denosumab”为主，研究方向呈现多元化。药物相关性颌骨坏死的研究热度总体呈上升趋势，核心聚焦于病理机制、风险因素与治疗策略。大型队列研究(LOE 2a)、高质量随机对照试验(LOE 1b)、GRADE系统评价与荟萃分析，以及临床实践指南等高等级证据显著推动了领域发展。展望未来，3D打印支架、干细胞疗法、新型生物材料及构建体外模型等组织工程与再生医学，有望为药物相关性颌骨坏死的骨修复、再生及机制研究提供突破性策略。
https://orcid.org/0000-0001-6309-0486 (唐正龙) 


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 药物相关性颌骨坏死, 骨改建, 高被引文献, 文献计量学, 知识图谱, 组织工程, 生物材料

Abstract: BACKGROUND: Bibliometric and visualization analyses of theme-related literature on medication-related osteonecrosis of the jaw are essential for gaining a comprehensive understanding of its research foundation and emerging trends.
OBJECTIVE: To reveal research hotspots, current status, and trends in medication-related osteonecrosis of the jaw through bibliometrics, citation analysis, and visualization analysis.
METHODS: The top 100 most-cited medication-related osteonecrosis of the jaw research articles published between 2004 and 2024 were retrieved and screened from the Web of Science Core Collection (SCI-Expanded). A bibliometric analysis was conducted to extract and analyze core characteristics such as annual publication volume, countries, institutions, authors, journal sources, and co-citation relationships, followed by the use of CiteSpace 6.4.R1 software to generate knowledge maps, thereby identifying research hotspots and emerging trends.
RESULTS AND CONCLUSION: The included literature accumulated a total of 12 337 citations, with an average annual citation rate of 6.17 citations per article. A stable and cohesive core international collaboration network exists. The United States, the University of London, and Professor Salvatore L. Ruggiero were the leading country, institution, and author, respectively, in contributing to the highly cited publications. Hotspot keywords primarily included risk factors, bisphosphonates, cancer, and osteoclasts, while “denosumab” emerged as a burst keyword, indicating a diversified research focus. Research interest in medication-related osteonecrosis of the jaw shows an overall upward trajectory, with a core focus on its pathological mechanisms, risk factors, and treatment strategies. High-level evidence, including large cohort studies (Level of Evidence [LOE] 2a), high-quality randomized controlled trials (LOE 1b), GRADE systematic reviews and meta-analyses, and clinical practice guidelines, has significantly advanced the field. Looking ahead, tissue engineering and regenerative medicine, encompassing the use of 3D-printed scaffolds, stem cell therapy, functionalized biomaterials, and in vitro models, are expected to provide breakthrough strategies for medication-related osteonecrosis of the jaw bone repair, regeneration, and mechanistic research.


Key words: medication-related osteonecrosis of the jaw, bone remodeling, highly cited papers, bibliometrics, knowledge graph, tissue engineering, biomaterials

中图分类号: