中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (10): 2525-2535.doi: 10.12307/2026.618

• 组织构建综述 tissue construction review • 上一篇    下一篇

痛风与部分生活方式、心血管疾病、骨骼疾病、精神类疾病的关系

刘书宏1，谢宇涵1，黄程程2，杨振国3，李  洋3   

  1. 1山东中医药大学中医学院，山东省济南市  250000；2山东中医药大学附属医院内分泌科，山东省济南市  250000；3山东中医药大学第二附属医院骨科，山东省济南市  250000
  • 收稿日期:2025-03-17 接受日期:2025-06-19 出版日期:2026-04-08 发布日期:2025-08-29
  • 通讯作者: 李洋，硕士，主治医师，山东中医药大学第二附属医院骨科，山东省济南市 250000
  • 作者简介:刘书宏，女，2001年生，山东中医药大学本科在读。
  • 基金资助:
    山东省中医药科技项目(M-2023143)，项目负责人：李洋；山东省医药卫生科技项目(202304071638)，项目负责人：杨振国

The relationship between gout and some lifestyles, cardiovascular disease, bone disease, and psychiatric disease

Liu Shuhong1, Xie Yuhan1, Huang Chengcheng2, Yang Zhenguo3, Li Yang3   

  1. 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250000, Shandong Province, China; 2Department of Endocrinology and Metabology, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, Shandong Province, China; 3Department of Orthopedics, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, Shandong Province, China 
  • Received:2025-03-17 Accepted:2025-06-19 Online:2026-04-08 Published:2025-08-29
  • Contact: Li Yang, MS, Attending physician, Department of Orthopedics, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, Shandong Province, China
  • About author:Liu Shuhong, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250000, Shandong Province, China
  • Supported by:
    Shandong Province Chinese Medicine Science and Technology Project, No. M-2023143 (to LY); Shandong Province Medicine and Health Science and Technology Project, No. 202304071638 (to YZG)

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摘要：


文题释义：
痛风：是单晶尿酸盐在血液中积聚，超出一定水平后在关节和其他组织中形成结晶导致的炎症反应，是以关节疼痛、活动受限、红肿发热为主要表现。此外，还易并发高血压、糖尿病及心血管疾病等各种疾病。
孟德尔随机化研究：是一种利用遗传变异作为工具变量来推断某个暴露因素与结果之间因果关系的统计方法，基本原理是基于孟德尔遗传定律，可以有效排除混杂因素和反向因果的干扰。近年来，随着全基因组关联研究的发展及大量汇总数据集的公开，孟德尔随机化研究方法已在医学各领域中应用。

背景：痛风发病与嘌呤代谢紊乱和/或尿酸排泄减少直接相关。目前痛风发病因素和与其他疾病的关系尚不完全清楚。孟德尔随机化研究可有效排除混杂因素和反向因果的干扰，为探究痛风与各种因素及疾病的关系提供了新的角度和思路。
目的：总结目前已发表的与痛风相关的孟德尔随机化研究，重点关注生活方式、多种疾病和代谢产物与痛风发生发展之间的因果关系。
方法：利用计算机检索中国知网和PubMed数据库2014-2024年期间发表的相关文献。中文检索词为“痛风，孟德尔随机化研究，因果关系，生活方式，饮酒，酒精，茶，咖啡，精神类疾病，阿尔茨海默症，心血管疾病，骨骼疾病，骨关节炎，高血压，心绞痛，肥胖”，英文检索词为“gout，Mendelian randomization，causality，lifestyle，drinking，alcohol，tea，coffee，mental illness，Alzheimer’s disease，cardiovascular disease，bone disease，osteoarthritis，hypertension，angina，obesity”，最终对88篇文献展开综述。
结果与结论：目前的孟德尔随机化研究结果大部分支持痛风与某些生活方式(如饮茶、咖啡等)、代谢产物、内分泌疾病、肥胖、心血管疾病、肠道菌群、微量营养素、COVID-19病毒感染、骨骼疾病、精神类疾病、基因表达之间存在因果关系，但部分孟德尔随机化研究结果不支持痛风与某些生活方式(如饮酒)、心血管疾病、骨骼疾病、精神类疾病之间存在因果关系。尽管孟德尔随机化研究存在一定局限性和不足，但研究结论为更全面了解痛风的发病因素及与其他疾病的关系提供了一定参考。
https://orcid.org/0000-0002-9226-9888(李洋)

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 痛风, 孟德尔随机化, 遗传变异, 因果关系, 生活方式, 心血管疾病, 骨骼疾病, 精神类疾病

Abstract: BACKGROUND: The onset of gout is directly associated with disorders of purine metabolism and/or reduced uric acid excretion. Currently, the etiological factors of gout and its relationship with other diseases are not fully understood. Mendelian randomization studies can effectively mitigate confounding factors and reverse causality, thereby providing novel perspectives and approaches for investigating the associations between gout and various risk factors/diseases.
OBJECTIVE: To summarize currently published Mendelian randomization studies related to gout, focusing on the causal relationship between lifestyles, various diseases and metabolites and the development of gout.
METHODS: A computerized search was conducted to identify relevant literature published in CNKI and PubMed databases from 2014 to 2024. The search terms were “gout, Mendelian randomization, causality, lifestyle, drinking, alcohol, tea, coffee, mental illness, Alzheimer’s disease, cardiovascular disease, bone disease, osteoarthritis, hypertension, angina, obesity” in Chinese and English, respectively. A total of 88 papers were finally included for review.
RESULTS AND CONCLUSION: Current Mendelian randomization studies predominantly support causal relationships between gout and various factors including lifestyles (e.g., tea/coffee consumption), metabolic products, endocrine disorders, obesity, cardiovascular diseases, gut microbiota, micronutrients, novel COVID-19 infection, skeletal disorders, and psychiatric diseases. However, some Mendelian randomization findings do not confirm a causal relationship between gout and some lifestyle conditions (e.g., alcohol consumption), cardiovascular diseases, skeletal disorders, or psychiatric diseases. Although there are some limitations and deficiencies in Mendelian randomization studies, the current conclusions still help us to have a more comprehensive understanding of the pathogenesis of gout and its relationship with other diseases.


Key words: gout, Mendelian randomization, genetic variation, causality, lifestyle, cardiovascular disease, skeletal disease, psychiatric diseases

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